Foundations of Medicinal Chemistry Flashcards
1
Q
Aromatic molecules follows what rule?
A
Huckel 4n+2
2
Q
Conditions to meet for an aromatic compound?
A
1) 4n+2 rule Pi electrons
2) Planar
3) Cyclic + conjugated
3
Q
What are carbocyclic (homocyclic) rings?
A
- Alkane/alkene ring structures
- Prefix “cyclo-“
- Multiple functional groups
- Possible combination with aromatic compounds.
4
Q
What are heterocycles?
A
- Ring structure formed with heteroatoms
- Heteroatoms= nitrogen, sulfur oxygen
- Synthetics, biomolecules
- Aromatic or not
- Mono or polycyclic
5
Q
What are lactones and lactames?
A
Condensed heterocycles deriving from carboxylic acids.
6
Q
What are lactones?
A
- Cyclic esters
- Note: Carboxylic acids + alcohol = esters
7
Q
What are lactames?
A
Cyclic amides
-Note: Carboxylic acid + NH2 functional group = Amides
