Solubility

Question 1

How to fix poor solubility?

Answer 1

1. Change the compound design - might not be possible depending on your target pKa’s, more acidic means more stable resultant anion and more likely to be ionised, more basic means higher pKa and more easily destablilised, ionisable molecules are more soluble in water
2. Create a salt - if the compound is ionisable a salt may be more soluble
3. Change formulation - make a capsule of lipids and place the drug inside which will then change the properties of the drug, liposomes, micelles, solid dispersion