Solid dosage form- tablets

Question 1

Tablet classifications?

Answer 1

immediate release and modified release

Question 2

Types of Immediate release tablet?

Answer 2

• Disintegrating
• Chewable
• Effervescent
• Sublingual and Buccal
• Lozenges

Question 3

Types of Modified release tablet?

Answer 3

• Prolonged-release
• Pulsatile-release
• Delayed-release

Question 4

Types of prolonged release tablet Diffusion controlled release system?

Answer 4

matrix and reservoir system

Question 5

Matrix system prolonged release?

Answer 5

Has pores to control drug diffusion

Question 6

Reservoir system prolonged release?

Answer 6

has membrane to control diffusion

Question 7

Stages of drug release for matrix system?

Answer 7

1- liquid penetrate the matrix and dissolve the drug
2- Form concentration gradient between interior and exterior
3- The drug diffuses in the pores

Question 8

Factors affecting drug diffusion for matrix system?

Answer 8

1. Concentration gradient
2. Area and distance over which diffusion occur
3. Diffusion coefficient of the drug in the diffusion media

Question 9

Stages of drug release for reservoir system?

Answer 9

1- liquid penetrate the matrix and dissolve the drug
2- Form concentration gradient between interior and exterior
3- The drug diffuses through the membrane

Question 10

Dissolution controlled release system with prolonged release tablets?

Answer 10

1. Decrease solubility of the drug by poor soluble salt form or derivative of the drug
2. Incorporate the drug into a slowly dissolving carriers
3. Covering the drug particles with slowly dissolving coating

Question 11

What is Pulsatile release?example

Answer 11

A number of small release unit with different coatings that has different dissolution times

Question 12

What is Delayed release – dissolution controlled release?

Answer 12

Gastro-resistant tablet the dissolution is inhibited until the preparation reaches higher pH of small intestine (PMMA)

Question 13

Erosion controlled release system of a Prolonged release tablet stages ?

Answer 13

1- The matrix material, which contain the drug, liberates from the surface
2- The drug dissolve in intestinal fluid and absorbed

Question 14

Osmosis controlled release system of a Prolonged release tablet stages?

Answer 14

1. Osmosis transport of liquid into the release unit
2. Dissolution of the drug within the unit
3. Osmotic transport of the drug through single orifice or pores

Question 15

Reasons for coatings on tablets?

Answer 15

o To protect the API from environment, in particular, moisture and light (improving product stability)
o To mask the bitter taste or otherwise unpleasant
o To improve the ease of swallowing large dosage forms
o Masking the batch differences in the appearance of the raw materials (over-the- counter products)
o To improve the appearance and aid in brand identification

Question 16

Types of coating process?

Answer 16

film, sugar and compression coating

Question 17

what is film coating?

Answer 17

involves deposition of a thin film of a polymer formulation on the surface of the tablet by a spraying method.(most popular technique)

Question 18

what is sugar coating?

Answer 18

involves application of sucrose-based coating formulation (syrup) to a tablet core, the water evaporates from the syrup and producing thick sugar layer (more traditional techniques).

Question 19

what is compression coating?

Answer 19

involves compaction of granule materials around a pre- formed tablet core in a dry process (used in modified- release products)