Solid Dosage form- Capsule

Question 1

why are some medications not available in oral forms?

Answer 1

they cannot be properly absorbed in the gastrointestinal tract

Question 2

what are the types of capsules?

Answer 2

• gelatin capsule, gel caps from collagen animals bones and skin
• vegetable capsule, from cellulose

Question 3

what are th different classifications of capsules?

Answer 3

• Hard capsule – filled with powders, tablets and semisolids

- Soft Capsule – filled with liquids

Question 4

parts of a hard capsule?

Answer 4

the body (longer main part) and cap (shorter top)

Question 5

advantages of capsule?

Answer 5

1. Capsules mask the taste and odour of unpleasant drugs and can be easily administered.
2. They are attractive in appearance
3. They are slippery when moist and, hence, easy to swallow with a draught of water.
4. As compared to tablets less adjuncts are required.
5. The shells are physiologically inert and easily and quickly digested in the gastrointestinal
6. They are economical
7. They are easy to handle and carry.
8. The shells can be opacified (with titanium dioxide) or coloured, to give protection from light.

Question 6

why is gelatin used in the development of capsule?

Answer 6

1. It is non-toxic,
2. It is readily soluble in biological fluids at body temperature.
3. It is good film-forming material, producing a strong flexible film
4. The gelatin films are homogeneous in structure, which gives them strength.

Question 7

what are some of the drawbacks that limit the use of gelatin in capsules?

Answer 7

• The animal source of gelatin can be a problem for certain consumers products.
• Transparent low-colour capsules are difficult to produce owing to the effect of the intrinsic Maillard reaction on gelatin colour.
• The temperature and moisture sensitivity of gelatin- based soft capsules is an issue that complicates the use of soft gelatin capsules in very hot and humid regions and requires special packaging and storage conditions to ensure product stability.
• Since unmodified gelatin is prone to cross linking when in contact with aldehydes, solubility problems might be expected with certain fill formulations.