Soft Tissue Tumours Flashcards
What is meant by a soft tissue tumour?
What structures tend to be implicated?
a tumour of non-bony mesenchymal structures
can involve connective tissue, muscle, fat and blood vessels
What are the 2 types of soft tissue tumours?
What age groups tend to be affected?
benign tumours are common
malignant tumours are rare
they occur in all age groups
What inherited conditions can predispose people to getting soft tissue tumours?
- Gardeners
- Li-Fraumeni syndrome
- neurofibromatosis
What viruses can predispose people to developing soft tissue tumours?
- HHV8 predisposes to kaposi’s sarcoma
- Epstein-Barr virus predisposes to smooth muscle tumours
How can radiotheraphy affect development of soft tissue tumours?
it can lead to angiosarcoma development, usually 10 years after treatment
What are the most common sites for malignant soft tissue tumours?
The thigh and retroperitoneum
soft tissue tumours can occur at any site in the body
What are the stages in medical management of soft tissue tumours?
- history
- examination
- radiology
- biopsy
- stage
- MDT
- treat and follow up
What is the common presentation of a soft tissue tumour?
most patients present with a lump
lumps are very common, but sarcomas are rare
What are the clinical clues that a ‘lump’ may be something more sinister?
- painful
- deep to deep fascia (not subcutaneous)
- > 5 cm in size
- recurrent
- enlarging
What are the radiological clues that a lump may be something more sinister?
- > 5cm
- deep to deep fascia
- heterogenous appearance
What is the only way to determine whether a soft tissue tumour is malignant or benign?
By taking a biopsy
What are the typical endings for a benign and malignant tumour?
benign - “oma”
malignant - “sarcoma”
What are the general names for the following tumours?
What are the 3 main problems with classifying soft tissue tumours?
- outdated names - synovial sarcoma is not actually in the synovium
- some have no normal tissue counterpart so can only be identified by patterns down the microscope
- some are named after the person who discovered them
What are the 3 things that might be carried out on a biopsy?
- histopathology (looking down a microscope)
this involves immunohistochemistry
- cytogenetics to look for chromosomal abnormalities
- molecular pathology
What is the purpose of immunohistochemistry?
it involves looking for certain proteins in cells to determine which cell type is present
What are the pitfalls when making a differential diagnosis of a soft tissue tumour biopsy?
- it could be lymphoma/leukaemia
- metastases - especially melanoma but also carcinoma and germ cell tumour
- reactive pseudotumour