Soft tissue tumors and lesions Flashcards
Stem cells that lead to muscle and bone cells
Mesenchymal stem cells
Where do soft tissue tumors arise from
extraskeletal mesenchymal cells
mesodermal origin
3 major categories of soft tissue tumors
adipose tissue
smooth muscle
skeletal muscle
Which type of soft tissue/lesion are common
BENIGN
Idiopathic soft tissue tumor
chemical burns thermal burns radiation therapy trauma viruses e.g. kaposi sarcoma in AIDS patients from Herpes virus 8
kaposi sarcoma
herpes virus 8
Sporadic soft tissue tumor
GENETIC
neurofibromatosis type I - from tumor suppressor function is defective
or p53 deficiency - Li-fraumeni syndrome
What is a type of sporadic soft tissue tumor that gives rise to telangiectasia on fingertips?
Osler-Weber-Rendu syndrome
What is the 4th common type of malignant tumor found in children?
sarcomas
Rhabomyosarcoma
in children
What is the most common site of soft tissue tumors/lesion
lower extremity
occur mostly in males over females
15% in children
Differentiate between rhabomyo vs synovial sarcoma
rhab in children
synovial in adults
In men, the most common SUBCUTANEOUS tumor is?
lipoma
liposarcoma
does not derive from lipoma which are BENIGN
lipomas
benign occur subcutaneous tether spinal cord ADULTHOOD usually on the elbow in men can show up anywhere mobile
subcategories of lipomas
fibro
angio
spindle cell
pleiomorphic
Liposarcomas
Common sarcomas of ADULTS
Age 40-60
UNCOMMON IN CHILDREN
differentiate lipoma vs liposarcoma DIAGNOSTIC
not CUTANEOUS
at retroperitoneal
deep soft tissue
Patient with fat nodule at the kidney
liposarcoma
can develop into very large masses
3 types of liposarcoma
- well - differentiated
- myxoid - mixed between benign and malignant type
- malignant type is the pleiomorphic
What is a rhabodomyosarcoma?
affects CHILDREN
skeletal muscle tumor
usually occur in GU or head an neck
a 16 year old comes in with grape like lesions in the vagina
she has Botryoide rhabdomyosarcoma
A 6 year old comes in with lesion on her orbit of the eye
Embryonal rhabdosarcoma
Differentiate botryoide rhabdomyosarcoma and leiomyoma
botryroid rhabdo is skeletal muscle lesion
leiomyoma is smooth muscle lesion
In leimyoma or fibroid or fibroma, what is the tissue affected
smooth muscle
A uterus with multiple lumpy bumpy lesions was shown
patient experiences bleeding and is now known to be infertile
leiomyoma
benign but painful
won’t progress to sarcoma
Leiomyoma vs leimyosarcoma
location !!!!!!!!
leiomyosarcoma is in the skin extremities like the foot
leimyosarcoma affects male or female more?
females
DO NOT evolve from leiomyomas
