Soft tissue tumors and lesions

Question 1

Stem cells that lead to muscle and bone cells

Answer 1

Mesenchymal stem cells

Question 2

Where do soft tissue tumors arise from

Answer 2

extraskeletal mesenchymal cells

mesodermal origin

Question 3

3 major categories of soft tissue tumors

Answer 3

adipose tissue
smooth muscle
skeletal muscle

Question 4

Which type of soft tissue/lesion are common

Answer 4

BENIGN

Question 5

Idiopathic soft tissue tumor

Answer 5

chemical burns 
thermal burns 
radiation therapy 
trauma 
viruses e.g. kaposi sarcoma in AIDS patients from Herpes virus 8

Question 6

kaposi sarcoma

Answer 6

herpes virus 8

Question 7

Sporadic soft tissue tumor

Answer 7

GENETIC
neurofibromatosis type I - from tumor suppressor function is defective
or p53 deficiency - Li-fraumeni syndrome

Question 8

What is a type of sporadic soft tissue tumor that gives rise to telangiectasia on fingertips?

Answer 8

Osler-Weber-Rendu syndrome

Question 9

What is the 4th common type of malignant tumor found in children?

Answer 9

sarcomas

Question 10

Rhabomyosarcoma

Answer 10

in children

Question 11

What is the most common site of soft tissue tumors/lesion

Answer 11

lower extremity
occur mostly in males over females
15% in children

Question 12

Differentiate between rhabomyo vs synovial sarcoma

Answer 12

rhab in children

synovial in adults

Question 13

In men, the most common SUBCUTANEOUS tumor is?

Answer 13

lipoma

Question 14

liposarcoma

Answer 14

does not derive from lipoma which are BENIGN

Question 15

lipomas

Answer 15

benign 
occur subcutaneous 
tether spinal cord 
ADULTHOOD 
usually on the elbow in men 
can show up anywhere 
mobile

Question 16

subcategories of lipomas

Answer 16

fibro
angio
spindle cell
pleiomorphic

Question 17

Liposarcomas

Answer 17

Common sarcomas of ADULTS
Age 40-60
UNCOMMON IN CHILDREN

Question 18

differentiate lipoma vs liposarcoma DIAGNOSTIC

Answer 18

not CUTANEOUS
at retroperitoneal
deep soft tissue

Question 19

Patient with fat nodule at the kidney

Answer 19

liposarcoma

can develop into very large masses

Question 20

3 types of liposarcoma

Answer 20

1. well - differentiated
2. myxoid - mixed between benign and malignant type
3. malignant type is the pleiomorphic

Question 21

What is a rhabodomyosarcoma?

Answer 21

affects CHILDREN
skeletal muscle tumor
usually occur in GU or head an neck

Question 22

a 16 year old comes in with grape like lesions in the vagina

Answer 22

she has Botryoide rhabdomyosarcoma

Question 23

A 6 year old comes in with lesion on her orbit of the eye

Answer 23

Embryonal rhabdosarcoma

Question 24

Differentiate botryoide rhabdomyosarcoma and leiomyoma

Answer 24

botryroid rhabdo is skeletal muscle lesion

leiomyoma is smooth muscle lesion

Question 25

In leimyoma or fibroid or fibroma, what is the tissue affected

Answer 25

smooth muscle

Question 26

A uterus with multiple lumpy bumpy lesions was shown

patient experiences bleeding and is now known to be infertile

Answer 26

leiomyoma
benign but painful
won’t progress to sarcoma

Question 27

Leiomyoma vs leimyosarcoma

Answer 27

location !!!!!!!!

leiomyosarcoma is in the skin extremities like the foot

Question 28

leimyosarcoma affects male or female more?

Answer 28

females

DO NOT evolve from leiomyomas