Soft Tissue Pathology

Question 1

Fibroma

Answer 1

• aka Traumatic Fibroma
• most common tumor of oral cavity
• Nodule of hyper plastic connective tissue

Question 2

Types of Fibroma

Answer 2

• Epulis Fissuration
• Giant Cell Fibroma
• Inflammatory Papillary hyperplasia

Question 3

Epulis Fissuration

Answer 3

• Fibroepithelial polyp or leaflike denture fibroma
• occurs underneath maxillary denture

Question 4

Giant Cell Fibroma

Answer 4

• not due to chronic irritation
• retrocuspid papilla
• most on gingiva
• disappear with age

Question 5

inflammatory Papillary Hyperplasia

Answer 5

• underneath denture
  
  • poor fit or new

Question 6

Fibrous Histiocytoma

Answer 6

• Fibroblastic and histiocyte differentiation
• Dermatofibroma
  
  • most common site
    
    • lesion on skin of extremities
• Oral lesions in adults
  
  • cutaneous lesion in children

Question 7

Fibrous Histiocytoma: histo

Answer 7

• Cartwheel pattern

Question 8

Solitary Fibrous Tumor

Answer 8

• mesothelial cells or Submesothelial fibroblasts
• NAB2-STAT6 fusion gene:
  
  • buccal mucosa-most common

Question 9

Solitary Fibrous Tumor: Histo

Answer 9

• Patternless Pattern
• Blood Vessels=”Staghorn” appearance

Question 10

Fibromatosis

Answer 10

• Middle ground b/w benign fibrous lesions and fibrosarcoma
• Juveniile Fibromatosis→in children
• para-mandibular soft tissue
  
  • destruction of bone
• Somatic mutation: B-catenin

Question 11

Fibromatosis: Histo

Answer 11

• Somatic mutation of B-catenin gene on 3q21

Question 12

Myofibroma

Answer 12

• Spindle cell neoplasm of myofibroblasts
  
  • both smooth and striated muscles

Question 13

Myofibroma: Histo

Answer 13

• Spindle cells w/blunted ends and eosinophilic cytoplasm

Question 14

Oral Focal Mucinosis

Answer 14

• overproduction of hyaluronic acid by fibroblasts
• Location:
  
  • Gingiva=most common

Question 15

Lipoma

Answer 15

• Benign Fat tumor
• Most common mesenchyme neoplasm

Question 16

What are some things that look yellow clinically?

Answer 16

• Fat
• Lymphoid tissue
• Keratin
• Purulent Exudate
• Calcifications
• Neural Tissue

Question 17

Traumatic Neuroma

Answer 17

• part of nerve was cut during a surgical procedure
  
  • proximal part tries to regrow
• Can be painful

Question 18

Solitary Circumscribed Neuroma

Answer 18

• aka Palisaded Encapsulated neuroma
• Benign neural tumor
• uncertain cause
• Histo:
  
  • Palisaded (NOT REALLY) encapsulated neuroma

Question 19

Multiple Endocrine Neoplasm 2B (MEN)

Answer 19

• Autosomal dominant
• tumor or hyperplasia of neuroendocrine tissues
• Type 1
  
  • MEN1 gene
• Type 2: RET proto-oncogene Chromosome 10
  
  • 2b
    
    • germline mutation on codon 918
• Clinical:
  
  • bilateral mucous neuromas

Question 20

Schwannoma

Answer 20

• Benign neoplasm of Schwan cells
• NF2
  
  • bilateral schwannomas
  • auditory-vestibular nerve
• can cause bony expansion if internal
• Types:
  
  • Ancient
  • Plexiform

Question 21

Schwannoma: Types

Answer 21

• Ancient
  
  • hemorrhaging
  • inflammation
  • degeneration tumor
• Plexiform
  
  • associated w/NF2 or schwannomatosis

Question 22

Schwannoma: Histo

Answer 22

• Antoni A & B with verocay bodies
• S-100 positive

Question 23

Neurofibroma

Answer 23

• common peripheral nerve neoplasm
  
  • Schwann and perineurial cells
• Location:
  
  • tongue & Buccal muscoa
    
    • most common
• Radiograph
  
  • intrabony with well-demarcated or poor defined unilocular or multilocular radiolucency

Question 24

Neurofibromatosis Type 1

Answer 24

• common hereditary condition
• FINISH

Question 25

Paraganglioma

Answer 25

• Etiology: Autonomic nerves or ganglion
• FINISH

Question 26

Congenital Epulis

Question 26

Congenital Epulis