small vessel vasculitis

Question 1

features

Answer 1

palpable purpura
raised non blanching diffuse erytghematous papukes and plaques
glomerulonephritis

Question 2

ZPAR 3

Answer 2

c anca anti neutrophilic cytoplasmic antibody

or anti proteinase 3 antibody are directed against proteinase 3 in cytoplasmic neutophil granules

c ANCA auto autoantibodies directed against proteinase 3

Question 3

pathophysiology

Answer 3

neutrophils of sensitized individuals express proteinase 3 and myeloperoxidase on cell surfeaces
auto antibody binds and neutrophil activates