Small Intestine/Colon 1 Path - Nelson

Question 1

3 overall causes of ischemic bowel disease?

Answer 1

Acute obstruction

Mesenteric Venous Thrombosis

Hypoperfusion

Question 2

Complications of transmural bowel necrosis?

Answer 2

Sepsis once the mucosal layer us broken down

Could cause septic shock and death

Question 3

What segments of bowel are most likely to be affected by ischemia?

Answer 3

Segments at the end of an arterial supply

Splenic flexure, sigmoid colon, rectum

Question 4

What is the name for a lesion consisting of malformed submucosa and mucosa blood vessels?

Answer 4

Angiodysplasia

• 20% of lower GI bleeds

Question 5

Quick Pathophysiology of celiac sprue:

Go!

Answer 5

• Gliatin in gluten triggers cytotoxic t-cell immune response
• Epithelial cell damage causes villous atrophy
• Malabsorption issues occur

Question 6

What is Whipple Disease?

Answer 6

Systemic infection with Tropheryma Whippelii

Organism-laden foamy macrophages accumulate in the lamina propria of small bowel (and other organs)

See diarrhea,weight loss, malabsorption, and abdominal pain

Question 7

What is abetalipoproteinemia?

Answer 7

It is an autosomal recessive mutation in the MTP protein

Presents in infancy with build-up of TGs in the cytoplasm because transepithelial transport of TGs can’t occur

See spiny burr cells