Small Animal Flashcards
What needs to be differentiated when assessing diarrhoea in small animals?
Acute or chronic
If acute with/without systemic signs
Small intestinal/large intestinal/mixed
Define diarrhoea
Increased frequency, volume or fluidity of stools
Define melaena
Dark, tarry faeces
Define flatulence
Excess gas
Define dyschezia
Difficult or painful defecation
What is melaena usually a sign of?
Upper GI bleeding
- Blood gets digested
Define haematochezia
Fresh blood in the stool
Define tenesmus
Ineffectual straining
How long should diarrhoea have gone on, even intermittently, before being classed as chronic?
Over 3 weeks
How does follow up differ between acute and chronic diarrhoea?
Acute
- Symptomatic treatment
- Treat signs
Chronic
- Investigation
- Underlying disease needs to be treated
What is used to determine whether diarrhoea is small intestinal, large intestinal or mixed?
History
- Differential diagnoses differ between diarrhoeas
What is the main difference between small intestinal and large intestinal diarrhoea?
Small intestinal could be GI or extra-GI
Large intestinal is confined to the colon
Describe small bowel diarrhoea
Large volume
Infrequent
Moderate weight loss
Little vomiting
Abnormal general condition
What are the 4 differential diagnoses for acute small intestinal diarrhoea with no other systemic signs?
Diet - main cause
Helminths
Protozoa (Giardia)
Iatrogenic (drugs)
What can give you a clue that acute diarrhoea has something more going on?
Flat, high heart rate - CVS problems
What are the differential diagnoses for acute small intestinal diarrhoea with systemic signs?
Bacterial infection - very rare
Viral infection
Toxins
Haemorrhagic gastroenteritis
Acute pancreatitis
How can bacterial infection with acute small intestine diarrhoea be diagnosed?
Faecal culture
How can acute small intestinal diarrhoea caused by viral infections be diagnosed?
Faecal antigen test
What are the differential diagnoses for acute large intestinal diarrhoea?
Whipworms
Clostridia
Giardia
Campylobacter
What will show up with chronic diarrhoea on physical examination?
Not that much
What are the differential diagnoses for chronic small intestinal diarrhoea caused by extra-GI?
Metabolic
- Hepatic disease
- Hyperthyroidism
- Addison’s disease
- Renal insufficiency
Pancreatic
- EPI
- Chronic pancreatitis
What usually presents with metabolic caused small intestine diarrhoea?
Other clinical signs
What are the differential diagnoses with chronic small intestine diarrhoea caused by primary problems?
Giardia infection
Chronic partial obstruction
Lymphangiectasia
Neoplasia
Food-responsive disease
Inflammatory Bowel Disease
What is the only place that chronic large intestinal diarrhoea occurs?
Colon
What are the differential diagnoses for chronic large intestinal diarrhoea?
IBD
Polyps
Food-responsive disease
Neoplasia
Chronic partial obstruction
Tritrichomonas foetus
What are the various investigations for chronic diarrhoea?
Faecal exam
Haematology, biochemistry, UA
Serum tests (TLI, LPI cobalamin)
Abdominal ultrasound
Empiric treatment with elimination diet
Biopses
Describe how biopsies are done via endoscopy
Multiple taken from stomach, proximal SI, ileum and colon
Non-invasive - except for anaesthesia
Direct visualization of mucosa possible
Gives diagnosis in most cases
Describe biopsies taken via exploratory laparotomy
Invasive - need to take care in sick animals, cats and animals with decreased albumin levels
Only yields 2-3 biopsies from stomach and small intestine
More expensive and painful for the animal
20% mortality vs 2% mortality for endoscopy
What are the four main causes for chronic small intestinal diarrhoea in the dog?
Food-responsive disease
Antibiotic-responsive diarrhoea
Inflammatory Bowel Disease
Neoplasia
How is food-responsive disease treated?
Elimination diet - protein that the animal hasn’t eaten before and usually broken down
Usually get better within the first 2 weeks
Keep on diet for at least 6-8 weeks
What breed is antibiotic responsive diarrhoea most commonly seen in?
German Shepherd Dogs
What is the treatment for antibiotic responsive diarrhoea?
Metronidazole 15mg/kg orally twice daily for 4 weeks
Usually relapse though
How is IBD diagnosed?
Clinical exclusion
What is the most common chronic enteropathy in dogs?
Inflammatory bowel disease
What are the three histopathologys of IBD?
Lymphoplasmacellular - most common
Eosinophilic - rare
Ulcerative colitis - only large intestine, rare in Boxers
What is the therapy for chronic enteropathies in dogs?
Elimination diet
Metronidazole 10-15mg/kg twice daily for 3-4 weeks
If no response then prednisolone 2.2mg/kg/d for at least 10 days then taper dose
Azathioprine or cyclosporine if steroids poorly tolerated
What is the terapy for IBD in cats?
Elimination diet
Prednisolone 2mg/kg/day for 10-14 days then slow
Chlorambucil if no response
Supplementation with cobalamin
Define protein losing enteropathy and its causes
Syndrome of intestinal diseases with non-selective protein loss - low albumin and globulins
Causes are IBD, lymphangiectasia and neoplasia
What can rabbits and rodents not do in regards to the GI tract?
Vomit
What is a vital dietary component of normal digestion of small furries?
Indigestible fibre
- Stimulate gut motility and dental wear
Digestible fibre
- Fermented by GI bacteria to produce fatty acids
What controls the large intestinal motility of rabbits?
Fusus coli
- Distal part of proximal colon
What happens to indigestible fibre and digestible fibre in rabbits?
Contractions separate indigestible fibre which is passed to produce pellets
Digestible fibre washed back to caecum for fermentation
Describe caecotrophy
3-8 hours after eating caecum contracts to produce mucus coated caecotrophs
Digested in intestines to provide:
- Microbial protein
- B and K vitamins
- Fatty acids
What do rodents still need even if eating caecotrophs?
B vitamins
What will some oral antibiotics cause in rabbits/rodents?
Death due to reduction in intestinal bacteria allowing overgrowth of others
What is gut stasis usually associated with in small furries?
Anorexia - can be potentially fatal
What are some common causes of gut stasis?
Stress
Dehydration
Anorexia
Pain
Primary GI disease
Toxin ingestion
Insufficient Fibre
When should primary GI disease be suspected with gut stasis in small furries?
History of poor diet
Dietary change
Abnormality palpable in gut
Onset preceded any development
Depression
Anorexia
When should secondary GI disease be suspected with gut stasis in small furries?
History of stress
Obvious source of pain
What should be done when a small furry presents with gut stasis after refining the problem?
Admit for supportive care and diagnostics
What five things need to be provided when stabilizing the rabbit with gut stasis?
Warmth
Fluids
Nutrition
Gut stimulants
Analgesia
What is the normal temperature for a rabbit?
38-39.5 ºC
What is the maintenance fluids for a rabbit?
<100ml/kg/day
How is fluid therapy often divided with rabbits?
Between IV and SC to reduce frequency
What fluid therapy is provided for rabbits with gut stasis?
Warm subcutaneous fluids with added hyaluronidase
Describe rabbit nutrition when supplied with gut stasis
50ml/kg/day split between 3-5 feeds if completely anorexic
Time and patience required
Nasogastric tube placement sometimes necessary
Describe cisapride use
Works on serotonin receptors
Indirectly stimulates Ach release
Works on:
- Oesophagus
- Stomach
- Small intestine
- Colon
More potent than metoclopramide
Why is gut stasis always a risk?
Gut stasis causes pain which causes gut stasis which causes pain etc.
What analgesia should be provided to rabbits with gut stasis?
NSAIDs (meloxicam) - <0.6mg/kg q12 hrs, ensure well hydrated and consider gastro-protectants
Opiods (buprenorphine) - <0.05mg/kg q6-8 hrs
When is surgery required with gut stasis?
Obstruction indicated by:
- Visualised foreign body
- Gastric dilation
- Gas shadows in small intestine
- Serial radiographs to see gas movement
When are blood tests indicated with rabbits?
If systemic disease suspected (renal failure, hepatic disease etc.)
What can indicate the severity of a condition on blood tests in rabbits?
Elevated glucose levels
What are some common causes of diarrhoea in rabbits?
Coccidiosis
Diet
Antibiotics
Post-weaning
Bacterial enteritis
Viral enteritis
What things can be used to diagnose the cause of diarrhoea in rabbits?
Faecal parasitology
Faecal microbiology
Abdominal imagining
Bloods
What four things should be provided to a rabbit with diarrhoea?
Warmth
Fluids
Nutrition
Analgesia
Describe large bowel diarrhoea
Small volume
Lots of mucus
Frequent
Tenesmus
Dyschezia
Little weight loss
Little vomiting
No change in general condition