Sm Intestine and Colon Path Pt 1

Question 1

Ileus

Answer 1

loss of normal peristalsis in absence of mechanical obstruction

Question 2

Hernia

Answer 2

defect in wall of peritoneal cavity, possible serousal pouch –> strangulation –> infarction

Question 3

Volvulus

Answer 3

complete twisting of bowel at mesenteric base

Question 4

Adhesions complication

Answer 4

may cause strangulation

Question 5

Intussusception

presentation

Answer 5

often presents with mass lesion

lesion gets “pulled in” to other bowel segment

Question 6

Meckel’s Diverticulum

Answer 6

true (mucosa, submucosa, muscularis propria)

failed involution of vitellline duct

Question 7

Global vs partical malabsorption

Answer 7

global: diffuse mucosal involvement or reduced absorbative surface
partial: interferes w/ limited # of nutrients

Question 8

Secretory diarrhea

Answer 8

isotonic stools

Question 9

Osmotic diarrhea

Answer 9

unabsorbed lumenal soluts

Question 10

Malabsorbative diarrhea

Answer 10

global nutrient malabsorption and steatorrhea

Question 11

Exudative diarrhea

Answer 11

bloody stools, neutrophillic infiltrate

Question 12

Celiac mechanism

Answer 12

gliadin-sensitivity, immune mediated enteropathy

Question 13

HLA subtypes associated with celiac

Answer 13

HLA-DQ2, -DQ8

Question 14

Pathologic findings of celiac

Answer 14

intraepithelial leukocytes (nonspecific)
villous atrophy w/ enlongated crypts
crypt hyperplasia

Question 15

Tropical sprue

Answer 15

mimics sprue after acute infection that affects distal small bowel

Question 16

Tropical sprue may cause…

Answer 16

vitamin B12 deficiency

Question 17

Abetalipoproteinemia

Answer 17

rare autosomal recessive
transepithelial transport defect: microsomal TAG transfer proteinemia
lipids accumulate in enterocytes

Question 18

Peripheral smear of abetalipoproteinemia

Answer 18

acanthocytes

Question 19

Whipple disease etiology

Answer 19

Gram + actinomycete T. whippelli, systemic infection

Question 20

Whipple disease pathology, progression

Answer 20

organism-laden macrophages cause lymphatic obstruction

can also accumulate in many places

Question 21

Most common disaccharide deficiency

Answer 21

acquired lactase deficiency

Question 22

Pancreatic insufficiency etiologies

Answer 22

CF in children
EtOH and stone disease in adults
carb absorption now affected