Iron and Copper Nutrition Flashcards
1
Q
Two oxidative states of iron
A
Fe2+ = ferrous Fe3+ = ferric
2
Q
Oxidative states of iron
interconversions
A
dietary: Fe3+
absorbed: Fe2+ (converted by brush border enzyme)
blood: Fe3+ bound to transferritin
3
Q
Fe3+ transported in blood via
A
transferritin
4
Q
Iron stored in enterocytes bound to
A
ferritin
5
Q
Regulation of Fe absorption
A
HFE gene, hepcidin high iron --> activates HFE gene hepcidin produced in liver hepcidin binds ferroportin on basolateral surface of enterocytes degradation of ferroportin decreased iron uptake
6
Q
Hemochromatosis etiology
A
HFE gene mutation
inability to produce functional hepcidin and therefore degrade ferroportin
7
Q
Copper oxidative states
A
Cu2+ –> Cu+ via brush border enzymes
8
Q
CTR1
A
transporter on apical surface for Cu
9
Q
Menkes kinky hair syndrome
A
ATP7A mutation
decreased uptake of Cu
hair normal at birth -> becomes brittle and sparse w/ age
hypothermia, hypotonia, FTT, seizures
10
Q
Wilson disease
A
ATP7B mutation
normally transports excess iron into bile for excretion
chelation Tx
