SLW Flashcards

1
Q

What is meant by a “nutraceutical” and “functional

foods”?

A

nutraceutical foods:
-“food, or parts of a food, that provide medical or health benefits, including the prevention and treatment of disease”

Functional foods:
- Functional foods are modified foods which claim to improve health, quality of life, or wellbeing. They are intended for use as part of a healthy lifestyle or as a means to compensate for an unhealthy one.

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2
Q

Some common examples of functional food are as follows:

A

➢ Probiotics - mostly bacteria which when taken in adequate amounts can confer a health benefit.
➢ Prebiotics - which can promote the growth of particular bacteria in the large intestine that are beneficial to the health of the intestine, and also inhibit the growth of potentially harmful bacteria.
➢ Stanols and sterols - occur naturally in small amounts in plants and fruits. They are thought to play a role in decreasing cholesterol levels.

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3
Q

What is glucosamine?

A

Glucosamine is an amino sugar that is naturally occuring in the body and it is normally involved in the making of glycosaminoglycans and glycoproteins. These are important components in maintaining and building parts of the joints such as the cartilage

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4
Q

What are the health claims of glucosamine?

A

It is most notably used to prevent and delay the progression of osteoarthritis

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5
Q

What are the side effects of taking glucosamine supplements?

A
➢ Gastrointestinal discomfort
➢ Constipation
➢ Diarrhoea
➢ Headaches
➢ Nausea
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6
Q

What is chondroitin?

A

It is naturally synthesised in the body and can be found in the bone cartilage. Chondroitin sulfate is a glycosaminoglycan and is a major component of articular cartilage. It can be used to help those who suffer from osteoarthritis. Chondroitin possibly results in the stimulation of the synthesis of proteoglycans and decreases catabolic activity of chondrocytes by inhibiting the synthesis of proteolytic enzymes that contribute to cartilage matrix damage. Chondroitin also exerts anti-inflammatory activity

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7
Q

What are the health claims of chondroitin

A

➢ Pain relief
➢ Slowing down the process of the cartilage breaking down (joint damage) to manage osteoarthritis
➢ Increase joint mobility
➢ Reduce inflammation

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8
Q

What are the side effects of taking chondroitin?

A
➢ Mild stomach pain
➢ Nausea
➢ Bloating
➢ Diarrhea
➢ Constipation
➢ Headache
➢ Swollen eyelids
➢ Leg swelling
➢ Hair loss
➢ Skin rash
➢ Irregular heartbeat
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9
Q

What is melatonin?

A

Melatonin is a naturally occurring hormone produced by the brain. It is involved in regulating a person’s body clock and helping to regulate sleep patterns. It is often recommended to manage ‘jet-lag’ (to re-establish normal sleeping pattern). In some countries melatonin is available to purchase as a supplement but in the UK, access is restricted to supply by prescription; Circadin is the only licensed melatonin product for use in the UK which is a prescription only medicine and it is available in the form of a ‘prolonged-release’ tablet. This is only licensed for short term treatment in adults of 55 years of age or over. However, it is used ‘off-label’ in children and young people under 18

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10
Q

What are the health claims of melatonin?

A

➢ Helps to promote sleep

Advantages of melatonin over other hypnotic agents include:
➢ No hangover effect.
➢ No risk of tolerance with repeated dosing.
➢ Therefore, no risk of physical dependence
➢ Low prevalence of unwanted effects.

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11
Q

What are the side effects of taking melatonin?

A
➢ Dizziness
➢ Headache
➢ Nausea
➢ Agitation
➢ Slight drop in body temperature
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12
Q

What advice about melatonin would you give to a patient?

A

Advise caution in patients who are pregnant, or have an autoimmune condition. Re-inforce to patients that this supplement is not available in the UK and they should be careful when using. This should not be used by children under the age of 12. Melatonin should be used with caution in patients using anticoagulants, as melatonin can reduce blood coagulation

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13
Q

What are plant sterols?

A

Plant sterols are steroid alkaloid bioactive component that have similar functions as that of mammalian cholesterols, but different in terms of their side-chain chemical structures. Some of the food sources of plant sterols include vegetable, nuts, margarines and soya. The traditional Mediterranean diet is characterised by a high intake of plant-sterol containing food

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14
Q

What are the health claims of plant sterols?

A

Plant sterols are mainly used to reduce low-density lipoprotein (LDL) cholesterol, which is also known as ‘bad cholesterol’. Plant sterols may reduce the risk of CVD as elevated LDL-cholesterol is one of the important risk factors for CVD.

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15
Q

What are the side effects of taking plant sterols?

A

To date, no serious side-effects of plant sterols consumption have been observed in humans.
However, some cases of diarrhoea in animals and humans have been reported at high doses of plant
sterol

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16
Q

What are isoflavones?

A
Isoflavones are polyphenolic compounds that possess both oestrogenic and anti-oestrogenic effects,
hence they are classified as phytoestrogens, defined as plant derived compounds with oestrogenic activity. Isoflavones are mainly found in plants of the Leguminosae family. The main sources of isoflavones are soy and soy-derived products. Other natural sources of isoflavones are red clover, kudzu, alfalfa, chickpeas, beans, and other which also belong to the Fabaceae family. Isoflavones belong to a class of compounds known as flavonoids.
Genistein, daidzein and glycetin are the principal isoflavones in the soya bean; these are usually found in the form of glycosides, which after ingestion are hydrolysed in the large intestine by the action of bacteria to release isoflavones
17
Q

What are the health claims of isoflavones?

A
➢ Prevention of cardiovascular disease
➢ Prevention of cancer
➢ Improve bone health (osteoporosis)
➢ Anti-inflammatory
➢ Antioxidant
➢ Reduce menopausal symptoms
➢ Positive effect on brain function
18
Q

What are the side effects of taking isoflavones?

A

➢ Stomach upset
➢ Nausea
➢ Possible increased risk of developing breast cancer
➢ Possible increased risk of thyroid disease
➢ Bloating
➢ Cramps
➢ Constipation
➢ Diarrhoea
➢ May cause migraine headaches in certain people

19
Q

Evidence for and against glucosamine

A

Evidence for:

  • Has been shown to improve joint pain
  • Can be given to patients who cannot take NSAIDs as an alternative

Evidence against:

  • Inconsistent evidence for helping with joint pain
  • Not shown to PREVENT osteoarthritis or strengthen bones
  • Not recommended by NICE
20
Q

Evidence for and against chondroitin

A

Evidence for:
- Limited long-term studies have shown benefits

Evidence against:
- NICE guidelines recommend avoiding chondroitin
- NICE also reviewed glucosamine and chondroitin alone
and together and found there was not much data supporting the reduction of pain and functional
improvement.
- The benefits for chondroitin are uncertain in symptom
relief in osteoarthritis and it is not appropriate for
osteoarthritis for the knee when it is used for disease
modification

21
Q

Chondroitin might increase the risk

A

of bleeding in patients who are already on anticoagulants. Those with blood clotting disorders should also be cautioned. Patients who are asthmatic
should be cautioned when using chondroitin as this may cause exacerbation

22
Q

Evidence for and against melatonin

A

Evidence for:
- Has been proven to improve sleep and to regulate internal body clocks in some studies

Evidence against:
- NICE does not recommend the supplement, however melatonin can be prescribed as POM as modified release tablets.

23
Q

Considerations of using melatonin

A
  • Advise caution in patients who are pregnant, or have an autoimmune condition.
  • Melatonin should also be used with caution in patients using anticoagulants, as it can reduce blood coagulation.
24
Q

Evidence for and against plant sterols

A

Evidence for:
- Has been proven to reduce LDL-C absorption hence reducing risk of CVD.

Evidence against:
- Insufficient evidence on the safety of plant sterols when taken at high doses! Not fully recommended by NICE.

25
Q

Considerations of using plant sterols

A

Individuals with mutated or deleted ABCG5 and ABCG8 genes, as these genes are responsible in controlling the absorption of plant sterols into the intestine.

26
Q

Evidence for and against isoflavones

A

Evidence for:

  • Has been shown to lower cardiovascular risk
  • Reducing cholesterol levels

Evidence against:
- Controversy exists over whether isoflavones increase or decrease breast cancer risk
- Ability to strengthen bones in humans is unknown
- Not recommended by NICE for women with breast
cancer

27
Q

Considerations of using isoflavones

A

Women with breast cancer should consult their pharmacists or doctors before taking isoflavones

28
Q

May cause diarrhoea when taken at high doses

A

plant sterols

29
Q

may help with osteoarthritis

A

chondroitin

30
Q

prolonged release formulation that legally requires a

prescription to be dispensed

A

melatonin

31
Q

often derived from shellfish

A

glucosamine

32
Q

may lower blood cholesterol level

A

plant sterols

33
Q

consumed in soya functional foods which may be beneficial for treating cardiovascular diseases

A

isoflavones

34
Q

have a theoretical risk of prolonged bleeding time

A

chondroitin