SLM Physiologic Changes in the Adult Population Flashcards
Error/cross-linkage theory of aging
Theory that errors in DNA/RNA synthesis accumulate over time, resulting in decreased biological function and ultimately cell death
Free Radical theory
Where products of metabolism, ie free radicals form ionic bonds with normal molecules in the body and destroy them. Damage accumulates with each free radical causing aging and death.
Wear and Tear Theory
Where physical, emotional, diet, and environmental factors place stress on cells, causing damage and the need for cells to adapt. Overuse and abuse of the cell’s metabolism due to stress causes aging and death
Programmed theory- biological clock
Theory that an individual is born with a pre-determined amount of replications of each cell. Thus, when replications reach fixed amount, the person dies.
immunological theory
Theory that decreased functioning of the immune system over time, mainly the T cells decreased ability to distinguish antigens, ultimately leads to more infections, immune disorders and cancer. These conditions then lead to death.
Neuroendocrine theory
Theory that changes in the neuroendocrine and immune systems change hormone levels and ability to fight infections, eventually causing aging and death.
Presbycardia
normal changes in the healthy heart that occur as the adult grows older. These normal changes are related to lifestyle, disease processes, smoking, diet, exercise, stress throughout life, and alcohol consumption.
Describe factors that can increase stress on the aging heart
illness or injury, extreme exercise or lack of “, emotional or environmental changes and certain meds
Atherosclerosis
build up of plaque on arterial walls that progressively occludes the lumen of the artery and obstructs blood flow. This also causes arteries to lose their elasticity, so they become stiff and can not dilate anymore.
Left ventricular hypertrophy
Thickening of the left ventricle myocardium in response to residual blood secondary to atherosclerosis (stiff arteries) and impaired blood flow. LV myocardium enlarges to accommodate for the volume of residual blood in the LV and for the increased pumping effort of heart.
According to jarvis, systolic blood pressures will rise 20mmhg within this age range, and then rise another 20mmhg in this second age range. What are the ages?
first rise is from 20-60 years
second rise is 60-80 years
Respiratory changes include aotf except:
a) decreased lung tissue elasticity
b) decreased vital capacity
c) decreased residual volume
d) increased A/P diamter of chest wall
c) decreased residual volume, the residual volume is increased with aging b/c of decreased elasticity, so the person is unable to maximally exhale air. This also causes the increased A/P chest diameter to increase.
EKG changes in the heart result in what?
changes to the sino-atrial node (pacemaker of the heart) causes a change in heart rate which can decrease CO and venous return, where some p’s will have S&S of inadequate blood volume.
What ability does elasticity of lung tissue refer to? What does elasticity decrease with age?
Elasticity refers to the ability of lung tissue to recoil during expiration and return to its resting state. Elasticity decreases due to a decrease in the amount of collagen and elastin in the lung tissue.
What is vital capacity and its normal total value?
When does VC decrease and what happens with this decrease?
the maximum volume of air that can be exhaled from the lungs following a maximum inspiration. The normal total for VC is 4800ml. This begins to decrease at age 50 and the individual will have increased residual volume. They also can’t effectively cough and deep breath.
What is the normal A/P diameter to transverse diameter ratio for the chest? Why does the A/P diameter increase with aging?
normal ratio is 1:2, A/P increases with aging due to decreased elasticity with decreased VC and increased amount of residual volume. The residual volume eventually causes hyperinflation of the upper lobes of the lungs and under inflation of the lower lobes.
What conditions can cause rigidity of the chest wall?
kyphosis, scoliosis, arthritis