Slide Deck 4 Flashcards
What are obligate intracellular bugs?
Stay inside (cells) when it is Really CHilly and COld. Rickettsia Chlamydia Coxiella
What are facultative intracellular bugs?
Some Nasty Bugs May Live FacultativeLY. Salmonella Neisseria Brucella Mycobacterium Listeria Francisella Legionella Yersinia pestis
Kid has cats, what happened, what bug? after you diagnose with serolgoy, how do you treat?
Patients present with bacillary angiomatosis. What is this, and why?
Cat scratch disease, caused by Bartonellosis henselae , flea transmitted or traumatically – most frequent of the Bartonellosis
leads to inflamed lymph node is shown
proliferation of endothelial cells, by NF-kB activation
patients present with little tumors that bleed on contact, comprised of endothelial cells “bacillary angiomatosis”
Azithromycin
What is verruga peruana?
the chronic delayed stage of infection by Bartonella bacilliformis.
It is a vasoproliferative manifestation of the infection characterized by 1–2 cm cutaneous nodules that are engorged with blood.
(Carrions disease: fever, headache, abdominal pain)
Endocarditis that doesn’t grow any bacteria?
Bartonella
The lone star tick bite spreads what? What are the symptoms, and what patients are most likelyaffected?
Ehrlichiosis
fever, red eyes (conjunctival injection), rash, fatigue, musle aches, nausea/vomiting/diarrhea
generally affects organ transplant and blood transfusion patients; it’s actually in 12% of people
What are these in your blood smears of monocytes? If they’re in the blood smears of granulocytes, then what is it an indicator for? How are these diseases transmitted?
Ehrlichiae! microcoloneis in monocytes are called morulae.
Morulae in granulocytes are an indicator for anaplasma, vector is Ixodes tick
MEGA berry
“Monocytes = Ehrlichiosis; Granulocytes = Anaplasmosis”
Between Anaplasmosis and Ehrlichiosis, which tick is responsible for which?
Ehrlichiosis: Lone Star
Anaplasmosis: Ixodes
What are the two groups of Rickettsia?
Typus group – includes prowazekii
Spotted fever group: includes typhii
Tick bite trasmission leads to fever, pain, systemic vasculitis: rash in 35-60%
What do you suspect, how do you diagnose? thereapy?
Rocky Mountain spotted fever (rickettsia)
Clinical–skin biopsy with NAAT
doxycycline
What causes epidemic typhus, and what does it look like? How do you treat it?
Rickettsia prowazekii
rash from trunk to extremities
can persist (Brill-Zinsser Disease)
tetracycline therapy
Which Rickettsial strain causes disease scrub typhus ? What does it follow?
Scrub typhus
Orienta tsutsugamushi
follows mite bite
infilitrate in lungs (pneumonia), headache, endocarditis (rare), fever, hepatitis, was around animals!
Coxiella burneti (no rash! Q fever!)
obligate intracellular
How does coxiella burneti infect humans?
Spores are contained in animal feces
Transmitted to humans via aerosol transmission
observed is a cell from anal area with lots of inclusion bodies. How is this grown on media? What type of stain do you have to use?
It can’t be. Chlamydia is an obligate intracellualr pathogen.
Giemsa stain
How does chlamydia enter cells, and what type secretion pathway?
It binds the outer membrane protein OMPc to glycosaminoglycans (GAGs), uses a type III secretion pathway.
What are the three forms of Chlamydia?
Chlamydia trachomatis, pneumoniae, psittaci (from birds)
What are the elementary and reticulate body of chlamydia?
Elementary body: smaller infectious form. Enters cell
Reticulate body: larger, replicative form. Replicates in cell.
For Chlamydia: Serovars D-K, what are the symptoms?
Women: vaginal discharge, dysuria, and pelvic inflammatory disease
Men: Urethral discharge, dysuria, testicular swelling