sleeping disorder

Question 1

Non-GABAergic hypnotics

Answer 1

1. Ramelteon- SE are dizziness, fatique, headache
2. Tasimelteon

• MT1 &MT2 agonists
• Melatonin R control the circardian rhythm
• used for insomnia
• rebound insomnia or drug abuse/withdrawal symtoms may arise

3.Suvorexant
- orexin ATG, hypnotic drug
-orexin A and B in hypothalamus are involved in the control of wakefullness
-loss of orexin neurons-narcolepsy
SE are unusual dreams, thoughts of suicide, addiciton

Question 2

Compounds with sedative hypnotic side effects

Answer 2

1. H1 ATG
2. antipsychotics and antidepressants
3. a2 AG
4. Opiates
5. antiepiletpics
6. scopolamine