anxiety disorder

Question 1

Serotonin in anxiety

Answer 1

• Non GABA ergic anxiolytics
• slow onset 1-3 weeks, no acute effects

1. SSRI, fluoxetine
   - antidepressant but also used to treat anxiety
   - one of the major group to treat panic attacks only chronically
   - may transiently increase anxiety so low dose in beginning and gradually increase and combine with BZD in beginning
2. Buspirone
   - selective anxiolytic with no sedative, hypnotic, anticonvulsant or muscle relaxant properties
   - it doesnt influence the GABAergic transmission

-PARTIAL AGONIST AT BRAIN 5-HT1a R.

• ADV: no dependance,sedation or intercations
• DISADV:slow onset of anxiolytic effect 1-3 weeks used in GENERAL ANXIETY but NOT very effective in panic disorders