Sleep-Wake DOs Flashcards
- Which are Non-Benzo BZRAs?
- Which are Benzos Hypnotics BZRAs?
- Eszopiclone, Zaleplon, Zolpidem
- Estazolam, Flurazepam, Temazepam, Triazolam, Quazepam
BZRAs = Benzo Receptor Agonists
- Non-Benzo BZRAs = Eszopiclone, Zaleplon, Zolpidem
- Benzo BZRAs = Estazolam, Flurazepam, Temazepam, Triazolam, Quazepam
1st line Pharm Tx options for Insomnia
Which sleeping DO is Doxepin and Ramelton used for?
Insomnia
Wake-promoting chemicals
- Orexin
- Catecholamine
- Histamine
Sleep-promoting chemicals
- GABA
- Serotonin
- Adenosine
- Melatonin
- Prostaglandin
Hypersomnolence Tx
- Modafinil (Non-amphetamine CNS Stimulant)
- Armodafinil, Methylphenidate, Amphetamines
- Oxybate Salts (Xywav) -> DEEP SLEEP (REMS Program d/t date rape)
- Mixed Oxybate salts (Xywav) is for _____
- Sodium Oxybate (Xyrem) is ONLY for ______
Narcolepsy or Hypersomnia
Xywav = Hypersomnia
Xyrem = Narcolepsy ONLY
What is Cataplexy? What sleeping DO is this commonly seen in?
Sudden muscle weakness
Narcolepsy Type 1
In order to be Dx with CHRONIC Insomnia, Hypersomnolence, or Narcolepsy, you must have difficulty ____ nights a week for 3mo+
3
Drug class?
* Daridorexant, Lemborexant, Suvorexant
Dual Orexin Receptor Antagonists (DORAs)
Orexin keeps you awake. Antagonize Orexin -> SLEEPY
Used for insomnia
Drug Class?
Doxepin
Low-dose Histamine Receptor Antagonist
used for insomnia
Drug Class?
Ramelteon
Melatonin Receptor Agonist
used for insomnia
Narcolepsy Tx
- Modafinil, Armodafinil, Pitolisant, Solriamfetol
- Amphetamines, Methylphenidate
- Severe sleepy & fail 1 med or Severe Cataplexy -> ADD or SWITCH Oxybates
- Residual Cataplexy -> Effexor, Fluoxetine, Duloxetine, TCA
- Milder Insomnia -> Short BZRA
- Peds -> Traditional stimulants or Oxybates
Hyperventilation -> _____
Hypoventilation -> _______
CPAP or BIPAP?
Hyperventilation -> CPAP
Hypoventilaiton -> BiPAP
OSA Dx
* ____ Apneas/Hr + SS
* _____Apneas/Hr (regardless if SS or not)
- 5 Apneas/Hr + SS
- 15 Apneas/Hr