Sleep Disorders (Insomnia) Flashcards

1
Q

What are immediate consequences of poor sleep?

A
  • less occupational productivity
  • less healthcare utilization
  • lower QOL
  • higher morbidity
  • daytime sleepiness
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

In what population do we commonly see sleep disorders?

A

geriatric

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

When do we see sleep disorders occuring?

A
  • difficulty falling asleep
  • poor sleep quality
  • frequent nighttime awakenings
  • early arousal without the ability to fall back asleep
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Why shouldn’t you self-treat a sleep disorder with alcohol?

A

Alcohol helps induce sleep, but reduces rapid eye movement (REM) sleep and suppresses breathing and can precipitate sleep apnea.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Definition of a short-term sleep disorder

A

less than 3 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Definition of a chronic sleep disorder

A

3+ sx/wk for at least 3 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

risk factors

A
  • female
  • increased age
  • medical or psychiatric comorbidities
  • substance abuse
  • emotional stress
  • work-related conditions (unemployed, night shift, changing shifts)
  • circadian rhythm disturbances
  • low socioeconomic status
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

DSM V Criteria

A

difficulty initiating or maintaining sleep, waking too early, or non-restorative or poor quality sleep DESPITE good opportunity and circumstances

AND (at least one):

  • fatigue or malaise
  • attention, concentration, or memory impairment
  • social or vocational dysfunction/ poor school performance
  • mood disturbance, irritability
  • daytime sleepiness
  • motivation, energy or initiative reduction
  • prone to errors/accidents at work/driving
  • tension, headaches, GI sx (due to sleep loss)
  • concerns/worries about sleep
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is primary insomnia?

A

tension and learned sleep-preventing associations
- vicious cycle: negative associations cause difficulty sleeping, which are then worsened by the patient’s concerns

(psychophysiologic insomnia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is secondary insomnia?

A

due to medical or psychiatric process

- treat the underlying condition here first!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the medical conditions that cause of secondary insomnia?

A
  • CV
  • Respiratory
  • chronic pain
  • endocrine disorders
  • GI
  • neurologic
  • pregnancy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the psychiatric conditions that cause secondary insomnia?

A
  • mood
  • anxiety
  • substance abuse
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What prescription drugs cause secondary insomnia?

A
  • anticonvulsants
  • central adrenergic blockers (clonidine, B-blockers, ACEis, methyldopa, reserpine)
  • diuretics
  • SSRIs, Bupropion, MAOis, TCADs
    Steroids
  • Stimulants
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What illegal drugs cause secondary insomnia?

A
  • cocaine

- methamphetamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Is treatment really necessary?

A

YES if:

  • impaired QOL
  • impaired cognitive function
  • incr. risk of: pain, depression, accidents, psych disorders
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How do we determine and treat ST insomnia?

A

< 12 wks + trigger (no psych/med conditions untreated)

shortest acting med 3-4x weekly for 3-4 wks then taper off

17
Q

How do we determine and treat chronic insomnia?

A

> 12 wks + (2 wks sleep diary OR insomnia questionnaire OR Epworth Sleepiness Scale)

Multi-modal Cognitive Behavioral Therapy (CBT)
- may combine with med in resistant cases

18
Q

What is CBT?

A

work with professional to understand root of problems and create a plan to change thinking (recognize one’s distortions in thinking, and reevaluate realistically; develop a greater sense of confidence is one’s own abilities) and behavioral (Facing one’s fears instead of avoiding them; Learning to calm one’s mind and relax one’s body) patterns

COGNITIVE BASED THERAPY

19
Q

What can we use as pharmacologic tx?

A

non-BZ hypnotic agents

  • alcohol
  • antihistamines
  • antidepressants
  • chloral hydrate
  • eszopiclone
  • melatonin
  • OTC (diphenhydramine, doxylamine)
  • Ramelteon
  • Suvorexant
  • Zolpidem
  • Zaleplon

BZDs

20
Q

What do we want to recommend for sleep onset +/- maintenance?

A

Eszopiclone or Suvorexant/Lemborexant (best options)

> Zolpidem

> BZDs (especially in older patients)

21
Q

What do we want to use for sleep onset ONLY?

A

Ramelteon > zaleoplon > triazolam

22
Q

What do we want to use for sleep maintenance?

A

Suvorexant/Lemborexant/doxepin - 3 mg/6mg doses

23
Q

6 General Steps to selecting/recommending therapy

A
  1. Short-term vs chronic
  2. primary vs secondary
  3. Epworth Sleepiness scale (is therapy necessary?)
  4. Assess sleep hygiene
  5. Determine type of sleep disturbance
  6. Evaluate patient characteristics, conditions, PMH,
24
Q

Which is more effective: CBT or pharmacologic therapy, for treating chronic insomnia?

A

CBT
(just as or more effective than pharm therapy)

  • CBT + pharm agents may have additional benefits
  • CBT can reduce medication need in patients on insomnia meds
25
Q

Which is more effective BZDs or BZD agonists?

A

Trick question! –> no significant differences in efficacy

26
Q

T/F: OTC agents, like diphenhydramine or doxylamine, should be used in treatment

A

FALSE

  • OTC are not recommended by AASM
27
Q

T/F: Orexin/hypocretin receptor antagonists and BZD-agonists have a better safety profile than BZDs

A

TRUE