SLE Missed in Monica's Stack

Question 1

What genetic contributions are associated with SLE?

Answer 1

Reduced C3 and C4
Anti C1q
Anti cardiolipin

Question 2

What are the main groups of gene polymorphisms that increase the risk of SLE?

Answer 2

1. Deficiency in complement: C1q, C3, C2, C4
2. MHC: HLA-DR2, HLA-DR3
3. Activation of innate immunity via TLR7
4. Activation of adaptive immunity from T and B cells reacting to auto-antigens on apoptotic cells

Question 3

What serology is the most specific for SLE?

Answer 3

ANA:
- Anti-sm
- Anti- dsDNA

Reduced C3 and C5

Question 4

What is the slightly less specific serology for SLE?

Answer 4

ANA:
- Anti Ro
- Anti La
- Anti-RNP
- Anti-phospholipid