SLE

Question 1

Environmental factors SLE

Answer 1

IV light
Female
EBV
Silica dust
Smoking

Question 2

Why female sex permissive to SLE

Answer 2

Estrogen activate sand prolongs survival of T and B cells

Question 3

Skin biopsy of SLE

Answer 3

Ig deposition at dermal-epidermal junction
Basal keratinocyte injury
T lymphocyte dominated inflammation

Question 4

SLE best screening test; most prevalent

Answer 4

ANA

Question 5

SLE; highly specific; correlated with disease activity, nephritis and vasculitis

Answer 5

Anti-dsDNA

Question 6

SLE specific (2)

Answer 6

Anti-dsDNA

Anti-Sm

Question 7

SLE; specific
Associated with anti-RNP
common in blacks and asians

Answer 7

Anti-Sm

Question 8

Associated with overlap features

Answer 8

Anti-RNP

Question 9

Associated with Sicca syndrome; subacute cutaneous lupus
Neonatal lupus
Congenital heart block

Answer 9

Anti-Ro (SS-A)

Question 10

SLE decrease risk for nephritis (2)

Answer 10

Anti-Ro (SS-A)

Anti-La (SS-B)

Question 11

Drug induced SLE

Answer 11

Anti-hi stone

Question 12

CNS Lupus

Answer 12

Anti-neuronal

Anti-Ribosomal P

Question 13

Most common vasculitis in SLE

Answer 13

Leukocytoclastic vasculitis

Question 14

Serum used to test dsDNA

Answer 14

Flagellate “Crithidia lucilae”

Question 15

Target INR APAS with lupus

Answer 15

1 ep of venous clotting: 2-2.5

Recurrent clots or arterial: 3-3.5