Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PSBIM nephro > GN > Flashcards

GN Flashcards

1
Q

Class of lupus nephritis with worst renal prognosis

A

Class IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Remission in Class IV lupus nephritis

A

Return to near-normal renal function and proteinuria =<330 mg/dL/day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Class of lupus nephritis that is predisposed to renal vein thrombosis and other thrombotic complications

A

Class V

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Target epitope for anti-GBM disease

A

a3 NC1 domain of collagen IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

In anti-GBM disease, this presentation is associated with bad outcome

A

Oliguria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Crescent formation in Bowman’a space

A

Anti-GBM disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Characteristic of IgA nephropathy

A

Episodic hematuria associated with IgA deposition in the mesangium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

In IgA nephropathy, greatest predictive power for adverse renal outcomes

A

Persistent proteinuria for 6 months or longer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q 
Wegener’s is associated with
A. Exposure to coal
B. a1-antitrypsin deficiency
C. Hepatitis B
D. Hepatitis C
A

B. a1-antitrypsin deficiency

Others: silica dust exposure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Type 1 MPGN biopsy

A

Double contour “tram-tracking”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Type II MPGN biopsy

A

Ribbons of dense deposits and C3 “dense deposit disease”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Type III MPGN biopsy

A

Focal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q 
Associated with nephrotic syndrome, except
A. Hodgkin’s disease
B. Allergies
C. NSAID use
D. All of the above
A

D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Electron microscopy of minimal change disease

A

Effacement of foot process

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Average protein excretion in 24 hours in nephrotic syndrome

A

10 grams

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Selective proteinuria

A

Minimal change disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

In minimal change disease, acute renal failure is often seen in these patients

A 
Low serum albumin
Intrarenal edema (nephrosarca)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Primary steroid responders

A

Complete remission after a single course of prednisone (<0.2mg/24hrs proteinuria)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Frequent relapsers

A

2 or more relapses in the 6 months following taper

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Adults are not considered steroid-resistant until ___ months of therapy

A

4 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

First line therapy in minimal change

A

Prednisone

22
Q

The following factors are associated with poor outcome in FSGS

A

Nephrotic-range proteinuria
African-American race
Renal insufficiency

23
Q

Most common cause of nephrotic syndrome in the elderly

A

Membranous glomerulonephritis

24
Q

Sensitive indicator for the presence of diabetes but correlated poorly with +/- clinically significant nephropathy

A

Thickening of the GBM

25
Q

Nodular glomerulosclerosis or Kimmelstiel-Wilson nodules is seen in

A

Diabetic nephropathy

26
Q

Earliest manifestation in DM nephropathy

A

Albuminuria

27
Q

Microalbuminuria

A

30-300 mg/24hrs

28
Q

When to test for microalbuminuria in type 1 and type 2 DM?

A

Type 1: 5 years after diagnosis

Type 2: at the time of diagnosis and yearly thereafter

29
Q

Potent risk factor for CV events and deaths in DM Type 2 patients

A

Microalbuminuria

30
Q

In DM nephropathy, kidney size is A. Normal
B. Enlarged
C. Decreased
D. A&B

A

D. Normal to enlarged

31
Q

After onset of proteinuria, DM nephropathy patients will reach renal failure over

A

Another 5-10 years

32
Q

Predicts which patients develop DM nephropathy

A

Hypertension

33
Q

Cast nephropathy vs light chain deposition disease

A

Cast nephropathy: renal failure but NOT heavy proteinuria or amyloidosis
Light chain deposition disease: produces nephrotic syndrome with renal failure

34
Q

True of primary amyloidosis
A. Lambda class
B. Associated with rheumatoid arthritis
C. Due to deposition of B-pleated sheets of serum amyloid A protein
D. Associated with ankylosing spondylitis or psoriatic arthritis

A

A.
associated with overt myeloma

B, C, D are characteristics of Secondary Amyloidosis

35
Q

Diagnostics for Renal Amyloidosis

A

Congo red
Liver or kidney biopsy
Abdominal fat pad aspirates

36
Q

Deficient lysosomal a-galactosidase A activity, resulting in excessive intracellular storage of globotriasylceramide

A

Fabry’s disease

37
Q

Seen on renal biopsy of Fabry’s disease

A

Zebra bodies

FSGS

38
Q

Urinalysis in Fabry’s

A

Maltese cross

39
Q

Associated with sensorineural deafness, hematuria, thinning and splitting of the GBMs

A

Alport’s syndrome

40
Q

X-linked inheritance of mutations in the a5(IV) collagen chain on chromosome Xq22-24

A

Alport’s syndrome

41
Q

Skin biopsy in cholesterol emboli

A

Biconvex clefts

42
Q

Best way to avoid progressive renal failure

A

Treating hypertension

43
Q

Renal biopsy of glomerular capillary endotheliosis

A

TTP/HUS

Preeclampsia/HELLP
Maligant hypertension
APAS

44
Q

Vascular nephropathy associated with ADAMTS13 deficiency

A

TTP/HUS

45
Q

Bacterial causes of TTP/HUS

A

E. coli 0157:H7

Shigella dysenteriae

46
Q

Treatment of adult TTP/HUS

A

Plasmapheresis

47
Q

HUS from infectious diarrhea should be given antibiotics

TRUE or FALSE

A

FALSE

it is thought to accelerate toxin release

48
Q

Lesion in HIVAN

A

FSGS

49
Q

HIV patients presenting with nephrotic-range proteinuria and hypoalbuminemia

A

FSGS

50
Q

Renal manifestations of hepatitis B

A

MPGN in adults
Renal artery aneurysms
Renal infarction
Ischemic scars

51
Q

Schistosomes most commonly associated with clinical renal disease

A

S. mansoni

PSBIM nephro (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions