SLE

Question 1

What is SLE?

Answer 1

Inflammatory autoimmune disorder
Affects multiple organ systemics
The production of autoantibodies directed against cell nuclei

Question 2

3 types of rash to know

Answer 2

Malar (butterfly rash)
Annular SCLE (subcutaneous lupus)
Discoid

Question 3

Mucocutaneous signs of SLE

Answer 3

Rash
Mouth ulcers
Non scarring alopecia

Question 4

Discoid lupus

Answer 4

Erythematous raised patches with adherent keratotic scaling and follicular plugging
Also atrophy, scarring, and telangiectasia

Question 5

Jaccoud’s arthropathy

Answer 5

Nonerosive

Reducible deformities

Question 6

Renal lupus nephritis

Answer 6

10% of patients progress to ESRD
Screen using urinalysis, urine ACR, monitor BP, peripheral edema
If proteinuria + hematuria: renal biopsy
Can present at any point of the disease and can have recurrent attacks

Question 7

Do NOT order ANA for…

Answer 7

Back pain
Fatigue NYD
Rash NYD
Hair loss NYD

Question 8

2 main treatments for SLE

Answer 8

Prednisone

Hydroxychloroquine

Question 9

Non pharm tx for SLE

Answer 9

Sun protection
Smoking cessation
Immunizations
Treat comorbid conditions

Question 10

Neonatal lupus

Answer 10

Transplacental passage of maternal anti-SSA/B antibodies

Risk of congenital heart block and cutaneous manifestations