SLE Flashcards
Joint inflammation due to a sterile inflammatory reaction following a recent infection
Female
Histopathologic features most suggestive of SLE
1) Renal findings 2) Skin findings, especially discoid rash
Deposition of immune complexes within the dermal-epidermal junction specific for SLE
Lupus band test
Hallmark of SLE
Generation of autoantibodies against self-antigens
Immune cells that demonstrate functional impairments in SLE
B and T cells
MC presenting complaints of children with SLE
Fever, fatigue, hematologic abnormalities, arthralgia, arthritis
Presence of 4 out of 11 of ___ simultaneously or cumulatively establishes the diagnosis of SLE
ACR 1997 Revised Classification Criteria for SLE
ACR 1997 Revised Classification Criteria for SLE
SOAP BRAIN MD: Serositis, Oral ulcers, Arthritis, Photosensitivity, Blood (hemolytic anemia, leukopenia, lymphopenia, thrombocytopenia), Renal, ANA, Immunologic abnormalities, Neurologic (seizure/psychosis), Malar rash, Discoid rash
Immunologic abnormalities in SLE
POSITIVE: Anti-dsDNA, anti-Sm, lupus anticoagulant, ANA; False positive RPR, Elevated anticardiolipin
Elevated in drug-induced SLE
Anti-histone antibodies
Antibodies specific for SLE
Anti-dsDNA
Antibody seen in SLE that correlates with disease activity
Anti-dsDNA
Anti-dsDNA correlates with SLE disease activity, particularly
Nephritis
Mainstay of treatment for significant manifestations of SLE
Corticosteroids
MCC of death in individuals with SLE in the first several years of diagnosis
1) Infection 2) Complications of GN 3) Neuropsychiatric disease
