SLE Flashcards
1
Q
Definition of SLE
A
A generalised connective tissue disorder affecting many organs and characterized by the production of many auto-antibodies, notably those against dsDNA
2
Q
Between which ages is SLE most common?
A
15-25
3
Q
Why does the incidence of SLE seem to be increasing?
A
- more sensitive tests
- milder cases being recognised
4
Q
Aetiology of SLE
A
- genetic (HLA DR3)
- infective
- hormonal
- immunological abberation
- drugs (hydrallazine, procainamide)
- breast augmentation
5
Q
Precipitating factors of SLE
A
- sun-exposure
- emotional/physical trauma
- infection
- drugs
6
Q
Pathogenesis of SLE
A
Immune complexes form locally or in circulation
- complement consumption
- release of inflammatory mediators increases inflammatory response increases vasculitis
7
Q
11 Criteria for classification of SLE
A
- malar rash
- discoid rash
- photosensitivity
- oral ulcers
- arthritis
- serositis
- renal disorder
- neurologic disorder
- haematologic disorder
- immunological disorder
- antinuclear antibodies
8
Q
Skin manifestations of SLE
A
- butterfly rash
- discoid lupus
- photosensitivity
- muscosal ulceration
- Raynaud’s phenomenon
- vasculitis
9
Q
Musculoskeletal manifetations of SLE
A
- arthralgia
- arthritis
- tendon rupture
10
Q
Respiratory manifestations of SLE
A
- pleurisy/effusion
- basal atelectasis
- restrictive lung disease
- alveolitis
- disappearing lungs
11
Q
CVS manifestations of SLE
A
- pericarditis
- myocarditis
- Libman-Sacks endocarditis
12
Q
Renal manifestations of SLE
A
- haematuria
- nephritis
- nephrotic syndrome
- renal failure
13
Q
Cerebral manifestations of SLE
A
- psychiatric
- neurological
14
Q
Haematological manifestations of SLE
A
- thrombocytopenia
- haemolytic anaemia
- leucopenia
15
Q
Constitutional symptoms of SLE
A
- weight loss
- malaise
- fever
- unexplained oedema
