SLE Flashcards
What are the 4 kinds of SLE
Discoid
Drug induced
Neonatal
Systemic lupus erythematosus
Describe discoid SLE
Limited to the skin
Identified by skin biopsy
Can evolve to systemic
10% of cases
Describe systemic lupus erythematosus
Multisystem
More severe than discoid
70% of cases
50% of cases impact a major organ
what two drugs are most commonly the cause of drug induced SLE
hydralazine hydrochloride and procainamide hydrochloride
decribe the primary defect in SLE
in regulation of immune system and development of autoantibodies due to defective B cell tolerance
Etiology of SLE
environment/ gut microbes, estrogen, antibiotics (by removing gut bacteria), and vitamins
what are the two most frequent causes of death in SLE
renal failure and infectious complications
what are internal signs of SLE
elevated antibodies: anti-dsDNA, anti-ribosomal P antibodies
decreased complement and WBCs
increased damage by immune complexes
lymphadenopathy in SLE
transient enlargment of peripheral and axial lymph nodes and splenomegaly
serositis in SLE
inflammation of the mesothelium
neuropsychiatric features of SLE
disturbances of mental function can develop secondary to the involvement of central/peripheral nervous systems
immunologic manifestations of SLE
B/T cells and dendritic cells are involved in pathogenesis characterized by loss of tolerance to nuclear antigens, formation of anti-nuclear antigens (ANAs), deposition of immune complexes in tissue, and multiorgan development
cellular aspects of SLE
defects in regulatory mechanism of the immune system
T suppressors reduced, hyperproduction of helper T cells
B lymphocyte hyperactivity against T cells
what is the humoral hallmark of SLE
circulating immune complexes and autoantibodies to almost any organ or tissue in the body
SLE is more common in
a. female infants
b. male infants
c. adolescent through middle-aged women
d. adolescent through middle-aged men
c. adolescent through middle aged wome
