rheumatoid arthritis Flashcards
how is RA defined
antibodies w/specificity for antigen determinants on the Fc fragment of human or certain animal IgG
what 4 factors are important in RA
genetic
hormonal
psychosomatic
immunologic
what is the most frequent cause of death in RA
cardiovascular disease
order of pathogenesis of RA
- initaion of synovitis
- subsequent immunologic events that perpetuate initial rxn
- transition of inflammatory rxn in synovium to proliferative, destructive tissue process
two pathogenic mechanisms for RA are
- immune complex hypothesis - antigen/ab interaction in synovial tissues
- cell-mediated - accumulation of t cells in synovium
diagnostic eval of RA
- low serum iron
- normal iron binding capacity
- elevated alpha 2 and gamma on electrophoresis
- RA, anti-CCP, ANAs, and immune complexes
is IgM RF specific for RA
no it is found in 70% of adults
what are cyclic citrullinated peptide antibodies
proteins that get altered during citrullination in RA inflammation that can induce autoimmune response
are anti-CCPs specific for RA
yes >95%, can be in preclinical phase
the worldwide incidence of RA is
a. 1-2%
b. 2-4%
c. 5-10%
d. more than 10%
a. 1-2%
all of the following are criteria for RA except
a. morning stiffness
b. evening stiffness
c. rheumatoid nodules
d. radiographic changes
b. evening stiffness
RF correlates with all the following except
a. the severity of the disease
b. the presence of nodules
c. other organ system involvement
d. age of pt
d. age of pt
in RA, vascular and parenchymal lesions suggest that lesions result from injury induced by immune complexes , especially those containing antibodies to
a. IgM
b. IgG
c. IgE
d. IgD
b. IgG
serum complement lvls are usually ___ in pt with RA
a. normal
b. decreased
c. increased
d. A or B
a. normal
