SLE Flashcards
4 categories of SLE etiology
UV light
viruses
hormonal
drug induced
4 main lupus-inducing drugs
- hydralazine
- procainamide
- minocycline
- TNF inhibitors
in simple terms, what is the pathogenesis of SLE
multiple contrbuting factors including genetics causing normal immune response in abnormal places; a type 3 hypersensitivity rxn
3 manifestations of CHILDHOOD SLE
fever
neurological disease
renal disease
list some clinical features of SLE (7)
- nonscarring alopencia
- cutaneous or ulcers
- raynaud’s
- arthritis
- leucopenia
- fever
- serositis
NOT conclusive list
list some clincial features of SLE (7)
- nonscarring alopencia
- cutaneous or ulcers
- raynaud’s
- arthritis
- leucopenia
- fever
- serositis
- ulnar deviation w/o erosions– need Xray to diff. from PsA or RA
NOT conclusive list
what is neonatal lupus
passive transfer of autoantibodies that wears out with time; baby does not actually have the disease; born with the butterfly rash
5 tests to order if suspecting SLE
- CBC w/ differential
- ESR/CRP
- creatinine
- urinalysis to check for proteinuria
- ANA (w/ immunofluorescence)
negative ANA means…
r/o SLE
4 other general things that could casuse + ANA
- thyroid disease– hypo-
- infxn– parovirus, lyme, etc
- fam hx
- other autoimmune dz
3 futher testing you can do after ANA
- ENA panel– assocaited with other dz
- dsDNA– rise is SLE specific
- complement– associated w/ dz activity (low is bad)
over ____ in the SLE classification criteria = likely lupus
10
what two tests are repeated after SLE diagnosis? what 3 tests do you get ONLY if there is major change in sx or physical findings
- dsDNA & c3/c4
- if major change: ANA, RF, CCP
NOTE: don’t recheck ESR/CRP
3 main goals of therapy with SLE
tx active lupus
prevent medication SE & damage
improve survival
gender & ethnicity most affected
Black ppl and latinos; mostly women
