Skin System Flashcards
What are the three main layers involved in the integumentary system
Epidermis
Dermis
Hypodermis
Describe hypodermis?
- not classified as a layer of skin but a layer of adipose tissue
- bottom layer
Function of hypodermis?
Protection
Insulation
Connects dermis to muscle and bone
Describe dermis?
middle layer
- Contains many structures including; elastic and reticular fibres, collagen, hair follicles, sweat glands, nerve endings, sebaceous glands and blood vessels
Function of Dermis
Epidermal nutrition - the blood vessels carry nutrients to epidermis and remove waste products
Provides strength - due to collagen
Provides flexibility - due to elastic fibres
Describe Epidermis?
- most superficial layer
- can vary in thickness e.g. 0.1mm on eyelids whereas 1mm on palms of hands
- avascular = lack of its own blood supply
What are the four main cells found in the epidermis?
Keratinocytes = for protection by forming a barrier
Melanocyetes = skin pigmentation
Langerhans cells = for immune response
Merkel Cells = form sensory structures
How many layers can epidermis be sub-divided to?
5 layers;
- stratum corneum
- stratum lucidum = only on fingertips, soles and palms
- stratum granulosum = granular cell layer
- stratum spinosum = spinous layer
- stratum basale = basal layer
What are the main functions of the skin?
Regulation of temperature:
- Vasoconstriction/ vasodilation = narrowing/widening of blood vessels
-sweating
-piloerection e.g. goosebumps
Protection
- physical barrier
- prevents water loss
Cutaneous sensation
- receptors within skin respond to temperature, touch, pressure and pain
Synthesis of Vitamin D
Excretion of waste products and sebum
Describe the skin response when warm?
Hair erector muscles relax
Sweat glands excrete sweat
Vessels dilate
Describe the skin response when cold?
Hair erector muscles contract
Sweat glands do not excrete sweat
Vessels constrict
What are the two cells involved in Immunity and protection?
Langerhans cells
Keratinocytes
Describe Langerhans cells?
- Formed in bone marrow and migrate to epidermis
- Engulf and breaks down pathogens
Describe Keratinocytes?
- Make up 90% of epidermal cell in humans
- Form a barrier against environmental damage
- Re - epithelialisation = wound healing
- Express cytokines to immune cells
- Prevent water loss at skin surface
- Apoptosis occurs at stratum granulosum layer
Describe Melanocytes?
- described as spider shaped cells
- located within the bottom layer of the epidermis
- synthesise melanin, the absorbed by keratinocytes
- keratin and melanin combined protect the skin from harmful effect of UV damage