Skin - principles, congenital disorders Flashcards

1
Q

Therapy of juvenile localised demodicosis

A
  • spontaneous healing (up to 90%)
  • no need for acaricid therapy, if small amounts of mites, but followup in every two weeks
  • if many mites: shampooing with follicular flushing effect: benzoyl-peroxide. + registered spot on Advocate (moxidectin) in every 4-2 weeks
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2
Q

therapy of generalized demodicosis

A
  • intense therapy + immunostimulation

- not registered by now: flusjing with amitraz 250-600 ppm in every 7-14 days

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3
Q

Therapy of feneralized demodicosis registered per os:

A
  • fluralaner (metabolised in liver), afoxolaner (metabolised in kidney), sarolaner (metabolised in liver), lotilaner (metabolised in liver)
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4
Q

Use of antibiotics in pyoderma:

- emirical

A

first line:

  • Cefalexin 2*30mg/kg: dont influence gut lora, narrow spectrum, but takes staph.
  • Cefadroxil 2*22mg/kg
  • (clindamycin, likomycin, szulfadimetoxin)
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5
Q

Use of antibiotics in pyoderma:

- based on resistance:

A
  • amox - clavulon

- cefovecin

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6
Q

antifungal therapy

A

Topically:
- imaverol solution, malaseb shampoo AUV
Systematically:
- itrakonazole (microsporum, candida, malassezia, aspergillus, leishmania, trypanosoma)
- terbinafin 8trichophyton)
- fluconazole (fungal meningitis and oral candida)

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7
Q

Alopecia

- “Black hair follicle dysplasia”

A

Occurrence:
- bearded collie, dachshound, papillon, basset
Clinical signs:
- from 4 weeks hairs fall out, fail to grow, scaling
Diagnosis:
- skin biopsy (abnormal follicles, with keratine plugs)
Treatment:
- antiseborrheoic shampoo (selenium disulphide, benzoyl peroxyde)

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8
Q

Alopecia

- Color mutant alopecia

A

“blue dobermann syndrome”, “blue dog disease”
Occurrence:
- in red and beige (fawn) dobermann, fawn irish setter + blue individuals of some other breeds
Clinical signs:
- at 1-3 years “moth eaten” alopecia on the back parts of the coat + increased scale + papule formation
Diagnosis:
- skin biopsy (cystic hair follicles filled with keratin)

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9
Q

Alopecia

- pattern alopecia Dachshound:

A
  • bilateral alopecia of the pinnae (males)
  • ventral alopecia (females)
  • no response to treatment
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10
Q

Alopecia:

- melanoderma and alopecia of yorkshire

A
  • onset at 6months-3years (both sex)
  • occurs at the nose and legs
  • spontaneous recovery is possible
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11
Q

Types of Alopecia:

A
  • Generalized (normal, pathological, naturally)
  • Hypotrichosis (siemese, devon rex cat)
  • Black hair follicle dysplasia
  • color mutant alopecia
  • pattern alopecia: dachs
  • melanoderma and alopecia in yorkshire
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12
Q

Types of Congenital pigmentation defects

A
  • Hereditary vitiligo
  • canine cyclic hematopoesis (grey collie syndrome)
  • tyrosinase deficiency in the chow-chow
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13
Q

Congenital pigmentation defects

- Hereditary vitiligo

A

Occurrence:
- GS, belgian shepherd, rottweiler, dobermann, old english shepherd, dachshund
Clinical signs:
- hypopigmentation on the nose, lip, buccal mucosa, facial skin, footpads, nails

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14
Q

Congenital pigmentation defects

- canine cyclic hematopoesis (grey collie syndrome)

A

Occurence: 6-12weeks
Clinical signs:
- pyrexia, lymphadenopathy, nonregenerative anemia, arthralgia, diarrhea
Course: lethal

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15
Q

Congenital pigmentation defects

- tyrosinase deficiency of Chow-chow

A
  • Cause: impared melanin synthesis
  • occurs in puppies: pink tounge, hair shafts turh white
  • sp. recovery
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16
Q

types of Abnormalities of structural integrity

A
  • Aplasia cutis (epitheliogenesis imperfecta)
  • cutaneous asthenia (Ehlers-Danos syndrome, rubber puppy disease, fibrodysplasia elastica) collagen dysplasia
  • dermatomyositis
  • canine ichtyosis (fish skin disease)
  • zinc-responsive dermatosis
  • Schnauzer comedo syndrome
  • Sebaceous adenitis (SA)
17
Q

Abnormalities of structural integrity:

- Aplasia cutis (epitheliogenesis imperfecta)

A
  • occurs in both dogs and cats
  • focal absence of epithelium where ulcers develop
  • course: +/- fatal (milder cases may heal or be treated)
18
Q

Abnormalities of structural integrity:

- cutaneous asthenia (Ehlers-Danos syndrome, rubber puppy disease, fibrodysplasia elastica) collagen dysplasia

A

Occurrence:
- beagle, dachs, boxer, st. bernard, GS, dobermann, himalayan cat, dsh cat
Clinical signs:
- soft, velvet like skin, too flexible skin, tear of skin without bleeding, poor healing, multiple scars, +/- vasopathy, cardiac valve disroder, humans: joint hyperfelxibility

19
Q

Abnormalities of structural integrity

- Dermatomyositis

A
  • Occurrence: rough collies, Shetland sheepdogs
  • Clin signs: from 3 month, lesions: papules, vesicles, pustules, crusts on the nose, eyes, tips of pinnae and tail, bony prominences of the feet + muscle atrophy
  • Diagnosis: skin + muscle biopsy
20
Q

Abnormalities of structural integrity:

- Canine ichtyosis (fish skin disease)

A

• generalized hyperkeratosis on the skin and foot-pads

  • Golden retriver ichtyosis (PNPLA1 gene)

• mild improvement to antiseborrheoic and keratolytic ointments

21
Q

Abnormalities of structural integrity:

- Zinc-responsive dermatosis

A

Hereditary zinz absorption defect: malamut, huskies

22
Q

Abnormalities of structural integrity:

- Schnauzer comedo syndrome

A
Occurrence: 
- exclusively male schnauzers
Clinical signs: 
- comedones along the dorsum, +/- papules, sec., folliculitis 
Treatment: 
- benzoyl peroxyde
23
Q

Abnormalities of structural integrity:

- Sebaceous adenitis (SA)

A

Occurrence:
- Vizsla, akita, samoyed, poodle
Clinical signs:
- on the trunk: scaling, alopecia, seborrhea
Treatment:
- antiseborrhoic drugs, cyclosporine 5mg/kg SID, isotretinoin 0.5-1mg/kg$24 hr p.o

24
Q

Types of Miscellaneous conditions, unknown etiology

A
  • Acanthosis nigricans

- Primary idiopathic seborrhea

25
Q

Miscellaneous conditions, unknown etiology

- Acanthosis nigricans

A
Occurrence: 
- exclusively dachs, 1-3 years
Cause: 
- multifactorial etiology?
Clinical signs: 
- typical localization, hyperpigmentation, lichenification 
Treatment: 
- predisolone 1mg/kg, vit E 400 IE/24hr, melatonin 2mg/dog/24hr for 3-5 days, then weekly/monthly
- limited response to treatment
26
Q

Miscellaneous conditions, unknown etiology

- Primary idiopathic seborrhea

A
  • occurs in cocker and springer spaniel

- rule out chronic dermatopathies