Skin Manifestations of Systemic Diseases

Question 1

How does erythema nodosum present?

Answer 1

Painful blue-red lesions on anterior shins

Question 2

What conditions can cause erythema nodosum?

Answer 2

Sarcoid
Strep infections
IBD
TB
Behcet's

Question 3

What drugs can cause erythema nodosum?

Answer 3

Sulfonamides

OCP

Question 4

How does erythema multiforme present?

Answer 4

Symmetrical traget lesions on palms, soles, and limbs

Question 5

What is the presentation of erythema multiforme possibly mediated by?

Answer 5

IgM deposition

Question 6

What is erythema multiforme usually secondary to?

Answer 6

Infection

Question 7

What infections can cause erythema multiforme?

Answer 7

HSV

Mycoplasma

Question 8

What drugs can cause erythema multiforme?

Answer 8

SNAPP

what is this?? idk lol

Question 9

What are Stevens-Johnson syndrome and TEN (toxic epidermal necrosis)?

Answer 9

Severe variants of erythema multiforme

Question 10

What causes Stevens-Johnson syndrome and TEN?

Answer 10

Nearly always drug induced

Question 11

How do Stevens-Johnsons syndrome and TEN present?

Answer 11

Fever

Mucosal and skin ulceration and necrosis

Question 12

How does pyoderma gangrenosum present?

Answer 12

Wide (10cm), deep ulceration with violent border, undermined edge, and purulent surface

Question 13

Where does pyoderma gangrenosum commonly occur?

Answer 13

On legs

Question 14

How does pyoderma gangrenosum appear once its healed?

Answer 14

Cribiform (pitted) scars

Question 15

What conditions is pyoderma grangrenosum associated with?

Answer 15

IBD
Autoimmune hepatitis 
Wegener's 
RA
Leukaemia

Question 16

How is pyoderma gangrenosum managed?

Answer 16

High-dose systemic steroids

Question 17

How does vitiligo present?

Answer 17

Chalky white patches with hyperpigmented borders

Question 18

What happens to vitiligo in sunlight?

Answer 18

Itches

Question 19

What is vitiligo associated with?

Answer 19

Autoimmune disorders

Question 20

How does livedo reticularis present?

Answer 20

Persistent mottled red/blue lesions that don’t blanch

Question 21

Where is livedo reticularis commonly found?

Answer 21

Legs

Question 22

What triggers livedo reticularis?

Answer 22

Cold

Question 23

What are the causes of livedo reticularis?

Answer 23

Idiopathic
Vasculitis
Obstruction
Sneddon’s syndrome

Question 24

What kinds of vasculitis can cause livedo reticularis?

Answer 24

RA
SLE
Polyarteritis nodosum

Question 25

What are the obstructive causes of livedo reticularis?

Answer 25

Anti-phospholipid syndrome | Cryoglobulinaemia

Question 26

What does Sneddon's syndrome consist of?

Answer 26

Livedo reticularis and CVAs

Question 27

What are the skin manifestations of rheumatic fever?

Answer 27

Erythema marginatum

Question 28

What are the skin manifestations of lyme?

Answer 28

Erythema chonicum migrans

Question 29

What are the skin manifestations of dermatomyositis?

Answer 29

``` Heliotrope rash on eyelids Macular rash Gottron's papules Mechanic's hands Nailfold erythema and telangiectasis ```

Question 30

What are the skin manifestations of diabetes mellitus?

Answer 30

``` Ulcers Candida Kyrle disease Acanthosis nigricans Necrobiosis lipoidica on shins Granuloma annulare on hands and feet ```

Question 31

What are the skin manifestations of sarcoidosis?

Answer 31

``` Erythema nodosum Erythema multiforme Lupus pernio Hypopigmented areas Red/violet plaques ```

Question 32

What are the skin manifestations of coeliac disease?

Answer 32

Dermatitis herpetiformis on elbows

Question 33

What are the skin manifestations of grave's disease?

Answer 33

Pre-tibial myxodema on lateral malleolus

Question 34

What are the skin manifestations of RA?

Answer 34

Rheumatoid nodules | Vasculitis appearing as palpable purpura

Question 35

What are the skin manifestations of SLE?

Answer 35

Facial butterfly rash

Question 36

What are the skin manifestations of systemic sclerosis?

Answer 36

``` Calcinosis Raynaud's Sclerodactyly Telangiectasia Generalised skin thickening ```

Question 37

What are the skin manifestations of liver disease?

Answer 37

``` Palmar erythema Spider naevi Gynaecomastia Decreased secondary sexual hair Jaundice Bruising Excoriations ```

Question 38

What are the skin manifestations of end-stage renal disease?

Answer 38

Pruritis Xerosis Pigment change Bullous disease

Question 39

What additional skin manifestations may be present with end-stage renal disease?

Answer 39

Manifestations associated with cause, or associated with transplant

Question 40

What skin manifestations may be associated with transplant in end-stage renal disease?

Answer 40

Cushingoid appearance Gingival hyperplasia Infections BCC, SCC, or melanoma

Question 41

What are the skin manifestations of neoplasia?

Answer 41

Acanthosis nigricans Dermatomyositis Thrombophlebitis migrans Acquired ichthyosis