Skin Conditions and Assoc Malignancies

Question 1

Acanthosis nigricans

Answer 1

Gastric cancer, genitourinary cancer

Question 2

Acute febrile neutrophilic dermatosis (sweet syndrome); acute onset erythematous papules or plaques that are sharply demarcated

Answer 2

Leukemia, especially AML

Question 3

Amyloidosis (primary systemic), pinch purpura, macroglossia, raccoon’s eyes, and waxy skin

Answer 3

Multiple myeloma

Question 4

Dermatomyositis, scaly red papules and plaques over bony prominences, heliotrope-violaceous periorbital eruption

Answer 4

Ovarian cancer (and others)

Question 5

Paraneoplastic pemphigus

Answer 5

Lymphoma, Castleman disease, CLL

Question 6

Paget disease of the breast (nipple “eczema”)

Answer 6

Breast cancer

Question 7

Necolytic migratory erythema (eczematous/psoriasiform eruption located around orifices/flexural/acral areas

Answer 7

Glucagonoma

Question 8

Keratoderma of the palms and soles (bilateral thickening of the epidermis)

Answer 8

SCC of the esophagus

Question 9

Explosive onset of multiple pruritic seborrheic keratoses (Leser-Trelat sign)

Answer 9

GI, breast, lung cancer

Question 10

Rugal folds on palms and soles (tripe palms)

Answer 10

GI adenocarcinoma, SCC, head/neck/lung ca

Question 11

Extramammary Paget disease (erythematous scaly plaque or patch on perineal skin, scotum or perianal area)

Answer 11

GI or genitourinary cancer, dematosis is also a malignancy and requires removal