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Q5 Dermatology > Skin Basics > Flashcards

Skin Basics Flashcards

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Dermatology Board Prep flashcards
1
Q

Dysfxn of Skin: Barrier

Results in? (4)

A

Injury
Dehydration
Infection
Inflammation

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2
Q

Dysfxn of Skin: Immune fxn

Results in? (4)

A

Infection
Cancer
Inflammation
Allergy

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3
Q

Dysfxn of Skin: Temp Regulation

Results in?

A

Hyper/Hypothermia

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4
Q

Dysfxn of Skin: Melanin Prdxn

Results in?

A

↓ protection from UV radiation

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5
Q

Dysfxn of Skin: Sensory

Results in? (3)

A

Pruritis
Dysesthesia
Insensitivity

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6
Q

Cutaneous Repair Phases? (4)

A

1) Coag
2) Inflammation
3) Proliferative (tissue formation)
4) Remodeling

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7
Q

Epidermis primarily made of?

A

keratinocytes

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8
Q

Dermis made of? (3)

A

Fibroblasts
Collagen
Elastin

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9
Q

Epidermis layers? (4)

A

1) Stratum corneum
2) Stratum granulosum
3) Stratum spinosum
4) Stratum basale

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10
Q

Stratum basal purpose?

Action?

A

Source of epidermal stem cells and keratinocytes

Cell division

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11
Q

Stratum spinosum consists of?

A

Desmosomal jxns -> hold keratinocytes together

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12
Q

Stratum granulosum purpose?

Filaggrin is?

A

Water barrier made of lipids from keratinocytes

Protein in granular layer -> keeps water in keratinocytes

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13
Q

Filaggrin mutations cause what diseases? (2)

A

Atopic dermatitis

Asthma

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14
Q

Stratum corneum made of?

Purpose?

A

Desquamating (flaking) keratinocytes -> keratinized non-nucleated cells

Trauma/Infection barrier

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15
Q

Bullous Pemphigoid is?

A

Epidermal dysfxn:

Autoimmune destruction beneath basal layer of epidermis -> causes blisters on erythematous base

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16
Q

Psoriasis is?

A

Epidermal dysfxn:

↑ turnover of epiderm -> thick scales

17
Q

Basal Cell CA presentation?

A

Pearly, erythematous papule w/ rolled borders and telangectasias

18
Q

Types of cells in epidermis? (3)

A

1) Keratinocytes
2) Melanocytes
3) Langerhans cells

19
Q

Melanocytes?

A

In basal layer of epiderm

Transfer melanin to keratinocytes

20
Q

Langerhans Cells?

A

Dendritic cells in mid-epiderm

Immune response

21
Q

Dermis purpose?

Contains? (7)

A

Flexible/tough support structure

Fibroblasts
Mast cells
Blood
Lymph vessels
Nerves
Sweat glands
Hair follicles
22
Q

Fibroblast purpose in dermis?

A

Synth and degradation of CT (wound healing/scarring)

23
Q

Mast cell purpose in dermis?

A

Mediated hypersensitivity rxn (urticaria, wheals)

24
Q

Subcutis made of?

Purpose? (3)

A

Fat

Insulation
Energy supply
Protection

25
Q

Panniculitis is?

A

Inflamm of SQ

e.g. Erythema Nodosum

26
Q

Adnexal structures in skin?

A

Pilosebaceous unit

Eccrine gland

27
Q

Pilosebaceous unit contains? (4)

A

Hair follicle
Sebaceous glands
Apocrine sweat gland (pits and anogenital only)
Arrector pili muscle

28
Q

Acne Vulgaris caused by?

A

Pilosebaceous unit dysfxn:

1) Plugged hair follicle by abnormal keratinization
2) P. acnes in follicle
3) Androgens
4) ↑ sebaceous gland activity

29
Q

Eccrine Glands? (3)

A

Don’t involve hair follicle
Present in all skin
Regulate temp

Q5 Dermatology (14 decks)

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