Skin and Systemic Disease Flashcards
Give 2 skin manifestations indicating genetic conditions leading to GI haemhorrage
Hereditary haemorrhagic telangiectasia (= red spots)
Blue rubber bleb navus (= blue spots)
Give 2 skin manifestations indicating inflammatory/autoimmune GI conditions
IBD:
Erythema nodosum
Pyoderma gangrenosum
Give the deratological clinical sign of scurvy/beriberi
Scorbutic gums
Give 5 dermatological signs of diabetes
Acanthosis nigricans Diabetic bullae Diabetic dermopathy - most common Eruptive xanthoms Necrobiosis lipoidica
Give a dermatological sign of hyperthyroid
Thyroid acropachy + dermopathy
Give a dermatological sign of hypothyroid
Pre-tibial myxoedema (can also occur in hyperthyroid)
Give 4 dermatological autoimmune conditions and any lil bits of info u know about them
- Cutaneous lupus - butterfly rash, clear margin plaques, photosensitivity, neg antibodies
Cutaneous vasculitis - small vessel is commonest
Alopecia - areata (DD scarring, androgenic); T-lymphocyte, cytokine rejection of hair
Vitiligo -segmental, generalised, destruction of melanocytes, associated with other autoimmune
What malignant cancer syndromes affect the skin?
Carcinoid syndrome
Ectopic ACTH
Pagets disease
Paraneoplastic pemphigus
Acquired hypertrichosis
Erythema Gyratum Repens
Bazex syndrome
Leser Trelat
Give signs of carcinoid syndrome
Episodic flushing (mins-hours) Facial telangiectasia GI carcinoid = liver mets Bronchial. ovarian = no mets
What differentiates carcinoid syndrome from menopause
No sweating in carcinoid
What tumour production of ACTH in ectopic ACTH syndrome lead to?
Generalised hyperpigmentation (inc MSH leads to inc melanin relase from melanocytes)
2 types of Pagets? Features?
Pagets (eczematous plaque at areola; extension of underlying ductal) + Extra-mammary Pagets (axilla or ano-genital areas; intraepithelial adenoca in 3/4)
What are the signs of paraneoplastic pemphigus?
Erosive stomatitis
Rash - ulcerations
Found in non-hodgkins; Castlemans
What is acquired hypertrichosis lanuginosa? What cancers is it a sign of?
Acute onset of lanugo hairs at face + body
Colorectal > lung > breast, usually advanced
What is the appearance of erythema hyratum repens? What cancers is it associated with?
Concentric erythematous lesions
Lung ca > oesophageal, breast
What is the appearance of Bazex Syndrome, and what cancers is it associated with?
Symmetrical hyperkeratosis of extremities
Bronchial, oropharyngeal, gastric, colon, biliary adenocarcinomas
What is the appearance of Leser-Trelat and what cancer is it associated with?
Eruptive seborrhoeic keratosis (lots of brown spots)
GI adenocarcinoma
In what cases may acanthosis nigricans be associated with malignancy (in particular gastric adenocarcinoma)?
Older patient, rapid onset
Involved lips
Weight loss
What is dermatomyositis and what cancers may it be associated with?
Inflammatory myopathy + rash (periorbital, gottrons papules, shawl sign, photosensitive)
Ovarian, breast, lung cancer
What 5 other syndromes may be associated with malignancy?
Bullous pemphigoid Sweets Syndrome Pyoderma gangrenosum Acquired ichthyosis Cryoglobulinaemia
Give some genetic tumour syndromes and their associated cancers
Peutz-Jeghers; colon Muir-Torre; GI, breast, GU Neurofibromatosis; nerve sheath, phaeoCCyT, carcinoid MEN syndromes; endocrine, P's Howel-Evans; oesophageal
