Skin

Question 1

Answer 1

A=epidermis

B=Dermis

C=Subcutaneous layer

D=Epidermal Ridges

E=Dermal Papillae

F=Tactile (sensory) receptor

G=Artery

H=Vein

I=Areolar Connective tissue

J=Adipose connective tissue

K=Papillary layer

L=Reticular layer

Question 2

Cells in Epidermis

Answer 2

Keratinocytes (squamous cells)

Melanocytes-pigment producing

Langerhans-antigen presenting

Merkel-tactile

Question 3

Answer 3

A=Stratum Corneum

B=Stratum Lucidum

C=Stratum Granulosum

D=Stratum spinosum

E=Stratum Basale

F= Dermis

G=Dead Keratinocytes

H=Living Keratinocytes

I=Melanocyte

J=epidermal dendritic cell

K=basement membrane

L=tactile cell

M=sensory nerve ending

Question 4

Stratum Basale

Answer 4

• Intense mitotic activity, contains progenator cells for all of epidermis
• Hemidesmosomes join cells to basal lamina
• Desmosomes bind these cells together
• Cells move upward during differentiation
• Basal cell carcinoma, Melanoma, Merkel Cell Carcinoma

Question 5

Stratum Spinosum

Answer 5

• Thickest layer consisting of polyhedral cells
• Thick skin (i.e. soles of feet) have a thicker layer of stratum spinosum
• Squamous cell carcinoma

Question 6

Stratum Granulosum

Answer 6

• Three to five layers of flattened cells, undergoing the terminal differentiation process of keratinization
• Cytoplasm is filled with keratohyaline granules and lamellar granules
• The lamellar granules undergo exocytosis, producing a lipid-rich, impermeable layer around the cells

Question 7

Stratum Lucidum

Answer 7

• only in thick skin
• thin, translucent layer of falttened eosiniphilic keratinocytes held together by desmosomes
• Nuclei and organelles have been lost
• cytoplasm has packed keratin filaments

Question 9

Stratum corneum

Answer 9

• 15-20 layers of squamous keratinized cell
• fully keratinized cells (squames) are shed at epidermal surface as desmosomes and lipid rich cell envelopes break down

Question 10

Eumelanins

Answer 10

• Brown or black pigments produced by melanocyte
• Red hair=pheomelanin

Question 11

Depigmentation-Vitiligo

Answer 11

• Acquired condition with loss or decreased activity of melanocytes (so no melanin)

Question 12

Dermatofibroma

Answer 12

• Neoplastic
• Fibroblasts, dendritic cells

Question 13

Dermatofibrosarcoma Proteburans

Answer 13

Fibroblasts

Question 14

Hemangioma

Answer 14

Endothelial cells (vessels)

Question 15

Hemangiosarcoma

Answer 15

Endothelial cells (vessels)