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Pathology Unit 2: Amyloidosis, Skin, Vasculitis, Joints, Autoimmune > Skin > Flashcards

Skin Flashcards

1
Q

which epidermal cell features HLA dr expression?

A

Langerhans cells

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2
Q

what cell type is responsible for skin color?

A

melanocytes

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3
Q

what epidermal cell type has neurosecretory function?

A

merckel cell

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4
Q

if a patient has a circumscribed area of hair loss on the scalp what is the dx?

A

alopecia areata

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5
Q

what group of disorders features epidermal thickening and scales?

A

ictheoses

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6
Q

which ictheosis is an autosomal dominant disorder of keratinization characterized by mild hyperkeratosis and reduced/abscent keratohyalin granules?

A

ictheosis vulgaris

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7
Q

what aut. dom disorder of keratinization is characterized by multifocal keratoses with the appearance of warty papules

A

daria disease of keratosis follicularis

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8
Q

what common proliferative skin disease is characterized by scaly plaques of persistent epidermal hyperplasia

A

psoriasis

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9
Q

penfigus bulgarisis a blistering skin disorder caused by antibodies to what antigen?

A

desmoglian 3

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10
Q

what disease features skin blister formation at the dermal epidermal interfce in response to minor trauma?

A

epidermolisi bullosa

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11
Q

in bulis penfagoid antibodies target antigens in which compartment of the skin?

A

basement membrane

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12
Q

gluten sensitivity is assoc with what pruritic cutaneous eruption?

A

dermatitis pepetiformis

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13
Q

erythema multiform is often a reaction to what type of blistering viral agent?

A

herpes symplex

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14
Q

what syndrome refers to an unusually sever form of erythema multiform that involves several mucosal surfaces and internal organs?

A

stevens johnson syndrome

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15
Q

if chronic skin involvement by lupus erythematosis is without the involvement of other organs what is the dx?

A

chronic cutantous lupus erythematosis or discoid lupus

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16
Q

what disease is a hypersensitivity rxn with lymphoytic inflitrates at the dermal epidermal junction and has a scaly appearance

A

licen planus

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17
Q

activation of which type of ab is involved in pathogenesis of verticaria

A

IgE

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18
Q

what aut dom skin disorder is caused by mut of C1 esterase inhib

A

heredityary angioedeme

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19
Q

what vascular skin lesion presents as palpable purpura and is an immune rxn that features neutrophilic inflamm

A

cutaneous necrotiing vasculitis or leukocytoplastic vasculitis

20
Q

what type of t lymph mediates the dermal rxn to poison ivy

A

cd4 positive t cells

21
Q

what benign self limited disrder features pallisading necrobiotic granulmas in the skin

A

granuloma annulare

22
Q

which sytemic disease cuases marked fibrosis and progressive tightening of the skin

A

scleroderma

23
Q

what cutaneous disorder manifests as self limited nonsuppurative tender nodules over the extensor surfaces of the lower extremities and is related to toxic and infectious agents

A

erythema nodosa

24
Q

what organism most often causes erythema injurata

A

m. tb

25
Q

what self limited condition is an inflammatory disorder of the sebaceous follicles that results in the intermettent formation of discrete papular or pustular formations and may lead to scarring

A

acne vulgaris

26
Q

what condition is caused by superficial bacterial skin infection by staph or strep

A

impetigo

27
Q

which organism can cause skin infection and can be diagnosed by india ink or musicarmine stains

A

cryptococcus neoformans

28
Q

which common and self limited skin infection features firm dome shaped smooth surface papules with a characteristic central umbilication

A

muluscum contagiousi=um

29
Q

how do we diagnose a localized skin lesion composed of benigh proliferation of melanocytes

A

nevus

30
Q

what type of nevus features nests of melanocytes in the epidermis and cells that have migrated into the dermis

A

compund nevus

31
Q

what is the most frequently encountered form of melanoma that is in the radial growth phase

A

superficial spreading melanoma

32
Q

what is the melanoma growth phase that follows the radial growth phase

A

vertical growth phasee

33
Q

how do we designate and elevated an spiroidal that has bipased the stepwise tumor progression of radial and vertical growth phases

A

nodular melanoma

34
Q

what type of melanoma presents as a large pigmented macule that occurs on the sundamaged sin usually in older caucasians

A

lentigo malignant melanoma or hutchinsons freckel

35
Q

ehat type of melanoma is mst common in dark skinned ppl and is usually limited to the palms soles and subungal region

A

acroletigionous melanoma

36
Q

what benign nevus usually occurs in children or adolescents and is composed of large atypical epitheloid melanocytes that can be mistaken for malignant melanoma

A

spits tumor

37
Q

what cutaneous tumor is caused by HPV

A

verucca

38
Q

how do we diagnose a wart that presents as a painful hyperkeratotic nodule on the sole of the feet

A

plantar wart

39
Q

what skin condition features scaly frequently pigmented elevated papues or plaques whose scales are easily rubbed off

A

sebbarea karatosis

40
Q

what is the most common malignant skin tumor in light skined people

A

basal cell carcinoma

41
Q

what type of malignant skin tumor resembles differentiated keratinocytes

A

squamous cell carcinoma

42
Q

what aggressive skin tumor of neurosecretory cells displays epithelial differentiation

A

merckel cell carcinoma

43
Q

what neoplasm differentiates toward hair structures

A

trichoepithelioma

44
Q

what skin neoplasm features infiltration by malignant helper t cells

A

mycosis fungoides

45
Q

what disorder referes to the systemic dissemination of mycosis fungoides

A

cesari syndrome

46
Q

what viruse is assoc with kaposi sarcoma with HIV

A

HHV8

47
Q

what is the cutaneous pseudoneoplastic proliferation of capillaries in respnse to bartonella species

A

baciliary angiomatosis

Pathology Unit 2: Amyloidosis, Skin, Vasculitis, Joints, Autoimmune (5 decks)

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