Skin

Question 1

which epidermal cell features HLA dr expression?

Answer 1

Langerhans cells

Question 2

what cell type is responsible for skin color?

Answer 2

melanocytes

Question 3

what epidermal cell type has neurosecretory function?

Answer 3

merckel cell

Question 4

if a patient has a circumscribed area of hair loss on the scalp what is the dx?

Answer 4

alopecia areata

Question 5

what group of disorders features epidermal thickening and scales?

Answer 5

ictheoses

Question 6

which ictheosis is an autosomal dominant disorder of keratinization characterized by mild hyperkeratosis and reduced/abscent keratohyalin granules?

Answer 6

ictheosis vulgaris

Question 7

what aut. dom disorder of keratinization is characterized by multifocal keratoses with the appearance of warty papules

Answer 7

daria disease of keratosis follicularis

Question 8

what common proliferative skin disease is characterized by scaly plaques of persistent epidermal hyperplasia

Answer 8

psoriasis

Question 9

penfigus bulgarisis a blistering skin disorder caused by antibodies to what antigen?

Answer 9

desmoglian 3

Question 10

what disease features skin blister formation at the dermal epidermal interfce in response to minor trauma?

Answer 10

epidermolisi bullosa

Question 11

in bulis penfagoid antibodies target antigens in which compartment of the skin?

Answer 11

basement membrane

Question 12

gluten sensitivity is assoc with what pruritic cutaneous eruption?

Answer 12

dermatitis pepetiformis

Question 13

erythema multiform is often a reaction to what type of blistering viral agent?

Answer 13

herpes symplex

Question 14

what syndrome refers to an unusually sever form of erythema multiform that involves several mucosal surfaces and internal organs?

Answer 14

stevens johnson syndrome

Question 15

if chronic skin involvement by lupus erythematosis is without the involvement of other organs what is the dx?

Answer 15

chronic cutantous lupus erythematosis or discoid lupus

Question 16

what disease is a hypersensitivity rxn with lymphoytic inflitrates at the dermal epidermal junction and has a scaly appearance

Answer 16

licen planus

Question 17

activation of which type of ab is involved in pathogenesis of verticaria

Answer 17

IgE

Question 18

what aut dom skin disorder is caused by mut of C1 esterase inhib

Answer 18

heredityary angioedeme

Question 19

what vascular skin lesion presents as palpable purpura and is an immune rxn that features neutrophilic inflamm

Answer 19

cutaneous necrotiing vasculitis or leukocytoplastic vasculitis

Question 20

what type of t lymph mediates the dermal rxn to poison ivy

Answer 20

cd4 positive t cells

Question 21

what benign self limited disrder features pallisading necrobiotic granulmas in the skin

Answer 21

granuloma annulare

Question 22

which sytemic disease cuases marked fibrosis and progressive tightening of the skin

Answer 22

scleroderma

Question 23

what cutaneous disorder manifests as self limited nonsuppurative tender nodules over the extensor surfaces of the lower extremities and is related to toxic and infectious agents

Answer 23

erythema nodosa

Question 24

what organism most often causes erythema injurata

Answer 24

m. tb

Question 25

what self limited condition is an inflammatory disorder of the sebaceous follicles that results in the intermettent formation of discrete papular or pustular formations and may lead to scarring

Answer 25

acne vulgaris

Question 26

what condition is caused by superficial bacterial skin infection by staph or strep

Answer 26

impetigo

Question 27

which organism can cause skin infection and can be diagnosed by india ink or musicarmine stains

Answer 27

cryptococcus neoformans

Question 28

which common and self limited skin infection features firm dome shaped smooth surface papules with a characteristic central umbilication

Answer 28

muluscum contagiousi=um

Question 29

how do we diagnose a localized skin lesion composed of benigh proliferation of melanocytes

Answer 29

nevus

Question 30

what type of nevus features nests of melanocytes in the epidermis and cells that have migrated into the dermis

Answer 30

compund nevus

Question 31

what is the most frequently encountered form of melanoma that is in the radial growth phase

Answer 31

superficial spreading melanoma

Question 32

what is the melanoma growth phase that follows the radial growth phase

Answer 32

vertical growth phasee

Question 33

how do we designate and elevated an spiroidal that has bipased the stepwise tumor progression of radial and vertical growth phases

Answer 33

nodular melanoma

Question 34

what type of melanoma presents as a large pigmented macule that occurs on the sundamaged sin usually in older caucasians

Answer 34

lentigo malignant melanoma or hutchinsons freckel

Question 35

ehat type of melanoma is mst common in dark skinned ppl and is usually limited to the palms soles and subungal region

Answer 35

acroletigionous melanoma

Question 36

what benign nevus usually occurs in children or adolescents and is composed of large atypical epitheloid melanocytes that can be mistaken for malignant melanoma

Answer 36

spits tumor

Question 37

what cutaneous tumor is caused by HPV

Answer 37

verucca

Question 38

how do we diagnose a wart that presents as a painful hyperkeratotic nodule on the sole of the feet

Answer 38

plantar wart

Question 39

what skin condition features scaly frequently pigmented elevated papues or plaques whose scales are easily rubbed off

Answer 39

sebbarea karatosis

Question 40

what is the most common malignant skin tumor in light skined people

Answer 40

basal cell carcinoma

Question 41

what type of malignant skin tumor resembles differentiated keratinocytes

Answer 41

squamous cell carcinoma

Question 42

what aggressive skin tumor of neurosecretory cells displays epithelial differentiation

Answer 42

merckel cell carcinoma

Question 43

what neoplasm differentiates toward hair structures

Answer 43

trichoepithelioma

Question 44

what skin neoplasm features infiltration by malignant helper t cells

Answer 44

mycosis fungoides

Question 45

what disorder referes to the systemic dissemination of mycosis fungoides

Answer 45

cesari syndrome

Question 46

what viruse is assoc with kaposi sarcoma with HIV

Answer 46

HHV8

Question 47

what is the cutaneous pseudoneoplastic proliferation of capillaries in respnse to bartonella species

Answer 47

baciliary angiomatosis