Skin Flashcards
S&S Non-melanoma
BCC: pink with raised borders and depressed centre
begins as a sore that will not heal
SCC: scaly, ulcerated, nodular
common areas; ears, temporal, scalp & neck
S&S Melanoma
Asymmetry Border Colour Diametre Evolution
development: melanocytes grow in clusters to form a mole (nevus)
S&S Merkle cell
Rare neuroendocrine tumour arises from the merkle (tactile) cells
these are located in the stratum basale & fxn in the sensation of touch
Epi/Eti Non Melanoma
Skin cancer= MC cancer
exposure to UVB
SCC: UV exposure, HPV, immunosuppression, thermal or electrical burns)
Epi/Eti Melanoma
UV light exposure then immunosupression
Epi/Eti Merkle cell
Caucasian males 50-80
Immunosuppression
Prognostic indicator Melanoma
Stage (tumour thickness)
ulceration
Routes of spread BCC
Local invasion and destruction
follows the path of least destruction
can destroy bone and cartilage
Routes of spread SCC & distant mets
lesions >1cm in size and 4mm in depth have a higher risk of metastasizing
regional lymphnodes often first met site then liver, bone and brain
Routes of Spread Melanoma and distant mets
Can be unpredictable
often lymphatic spread
can metastasize to any location
more aggressive than BCC and SCC
lung then liver, bone, brain
Pre-malignant lesions
1) senile keratosis
2) keratoacanthoma
3) leukoplakia
Pathology Melanoma
classified according to growth patterns and histological appearances
Superficial spreading melanoma (SSM)
-70% of lesions exhibit radial growth pattern in epidermis
Nodular melanomas (NM) -15-30% of lesions vertical growth, most aggressive
RT & doses non-melanoma
Usually sx than RT
Palliative role is common
Small–> 30/10 40/10
Large–> 45-55 or 60-70
RT & dose Melanoma
Radioresistant
Main role for RT is for high-risk, recurrent or met disease
30/5 or 50-60
palliative: 20/5 or 30/10
