Skin Flashcards

1
Q

Ipx to distinguish between skin primary neoplasm vs metastasis to skin

A

skin tumour cells express CK5/6, p63, D2-40

if not then it is likely a metastasis.

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2
Q

IPx to confirm Mycosis Fungoides

A

CD4 positive and CD8 negative or positive epidermotropic lymphocytes.
Large cell transformation - CD3 positive in large tumour cells. CD30 positivity often in large cells but not required for diagnosis. Large tumor cells are also often CD25(+)

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