california set 1 2017-2018 hematolymphoid

Question 1

Plasma cell marker

Answer 1

CD38 - mature plasma cells

Question 2

common locations for extramedullary plasmacytoma

Answer 2

head, neck, upper respiratory tract are common,

unusual locations - thyroid

Question 3

what is castleman’s disease?

Answer 3

AKA angiofollicular hyperplasia or giant lymph node hyperplasia

rare lymphoproliferative disorder

three histologic variant - hyaline-vascular, plasma cell, mixed,

Unicentric CD- affect all ages, no gender predilection, most common in mediastinum, solitary mass

multicentric CD - predominantly HIV, HHV8, infection. Often present as multifocal cervical lymphadenopathy with associated cytopenia. More likely to be mixed hyaline-vascular, and plasma cell variants.

Question 4

what does CD163 and CD68 stain?

Answer 4

CD 163
Positive staining - normal: monocytes / macrophages
Positive staining - disease: histiocytic sarcoma

CD68
Macrophage / monocytes, Langerhans cells, mast cells, myeloid cells, CD34+ progenitor cells, neutrophils, osteoclasts, activated platelets and B and T cells