Skeletal muscle relaxants Flashcards
Spasticity
intermittent or sustained contraction of skeletal muscle
neuromuscualr blockers MOA
produce paralysis
does not pass the BBB
highly ionized
lacks CNS activity
interfere with the transmission at the neuromuscualr end plate
drugs for acute spasm
carisoprodol
cyclobenzaprien
drugs for chronic spasm : centrally acting
diazepam
gabapentin
pregabalin
direct acting drugs for spasm
botulinum toxin
Cyclobenxaprine MOA
inhibition of spinal stretch refelx
exact mechanism is unknown but might affect brainstem
both a sedative and antichlinergic
which antispasm drug is safe in pregnancy
cyclobenzapine
cyclobenzapine side effects
anticholinergic effects:
sedation
confusion
ocular effects like hallucination
which antispasm drug is usually prefereed in acute spasm
cyclobenzaprine
carisoprodol MOA
MOA is unknown but it might affect the brainstem
blocks intraneural activity in the spine and reticular formation in the brain
