Sjogren's syndrome

Question 1

Epidemiology

Answer 1

Primary:
F»M=9:1
Onset: 40 - 50 yo

Secondary:
RA, SLE or systemic Sclerosis

Question 2

Features of Sjogren’s

Answer 2

Features:
 ↓ tear production → dry eyes
↓ salivation → xerostomia
Bilateral parotid swelling
Vaginal dryness → dyspareunia
Fatigue 
Dry mucous membranes

Question 3

Systemic features

Answer 3

Polyarthritis
Raynaud’s
Vasculitis
Myositis

Question 4

Ix of sjogren’s

Answer 4

Schirmer tear test
Abs: ANA – Ro and La, RF
Hypergammaglobulinaema
Parotid biopsy

Question 5

Mx of sjogren’s

Answer 5

Artificial tears
Saliva replacement solutions
NSAIDs and hydroxychloroquine for arthralgia
Immunosuppression for severe systemic disease