Sjogren's Flashcards
1
Q
What is Sjogren’s?
A
- Autoimmune inflammatory disorder
- Diminished lacrimal and salivary gland secretion
2
Q
Two forms of Sjogrens
A
Primary - not associated with other diseases
Secondary- associated with underlying rheumatic disease
3
Q
Male or female?
A
80% female
4
Q
Common symptoms of Sjogrens
A
- Myalgia
- Arthralgia
- Dry mouth
- Fatigue
- Raynaud’s
- Enlarged parotids
- Dry eyes
MADFRED
5
Q
Presentation of Sjogrens
A
Sicca symptoms:
* Xerophthalmia (dry eyes)
* Xerostomia (dry mouth)
* Fatigue
6
Q
Investigation for Sjogrens
A
- Schirmers test - filter paper in eye, measures tear volume
- Salivary gladn biopsy?
7
Q
Antibodies in Sjogrens
A
- Anti-Ro and Anti-La
- RF and anti-dsDNA may be seen
8
Q
Treatment for Sjogrens
A
- Symptomatic
- Avoid dry/smoky atmospheres
- Dry eyes - artificial tears
- Dry moith - artifical saliva, sugar free gum/pastilles
- Skin emoillients
- Vaginal lubricants
- Immunosupression/steroids rarely needed
9
Q
Common diseases associated with Sjogrens
A
- SLE
- Systemic sclerosis
- Rheumatoid arthiritis
10
Q
Other autoimmune conditions associated with Sjogrens
A
- Coeliac
- Primary biliary cirrhosis
- Autoimmune thyroid disease
11
Q
Serious risk associated with Sjogrens
A
- 5-10% lifetime risk B cell lymphoma
12
Q
Pregnancy and Sjogrens
A
If positive for anti Ro, risk of:
* Fetal loss
* Complete heart block fetus
* Neonatal lupus syndrome in newborn
13
Q
Biopsy for Sjogrens
A
Focal lymphocytic infiltration of exocrine gland
14
Q
A
