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Rheumatology YR3 > Antibodies and Drugs > Flashcards

Antibodies and Drugs Flashcards

1
Q

What is anti-dsDNA associated with?

A
  • SLE
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2
Q

What is anti-Ro and anti-La associated with?

A

SLE
Sjogrens

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3
Q

What are anti-centromere and anti Scl70 associated with?

A

Systemic scelrosis

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4
Q

What is anti Jo-1 associated with?

A

Polymyositis

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5
Q

What is the only antibody which rises with disease severity?

A

Anti-dsDNA

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6
Q

What is reduced in SLE flares?

A

Complement C3 and C4

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7
Q

What is c-ANCA associated with?

A
  • GPA
  • Infection
  • Neoplasia
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8
Q

What is p-ANCA associated with?

A
  • Microscopic polyangitis
  • Infection
  • Neoplasia
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9
Q

What are corticosteroids main treatment for?

A

Polymyalgia rheumatica
Giant cell arteritis

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10
Q

What diseases are DMARDs mainly used in?

A
  • Rheumatoid arthirits
  • Psoriatic arthitritis
  • SLE
  • Vasculitis
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11
Q

Most common three DMARDs for inflammatory arthirit s

A
  • Methotrexate
  • Hydroxychloroquine
  • Sulfasalazine
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12
Q

Which DMARDs are contraindicated in pregnancy and breastfeeding?

A
  • MTX
  • Leflunomide
  • Cyclophosphamide
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13
Q

Who are biologics used for?

A

RA
Psoriatic arthiritis
Ankylosing spondylitis

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14
Q

Best DMARD RA

A

Rituximab - CD20 inhibitor or
Tocilizumab - IL-6 inhibitor

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15
Q

AS and Psoratic arthitis DMARD

A
  • IL-17A antiagonists
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16
Q

What is important to screen for if giving DMARDs?

A
  • Latent TB
  • Hepatitis B
17
Q

Vaccination advice for those with AI disease

A
  • Annual influenza advised
  • Pneumococcal advisable for some
  • Live vaccinations should be avoided in more immunosupressive DMARDs eg MTX, azathioprine, ciclosporin, leflunomide
18
Q

Adverse effects of MTX

A
  • Nausea
  • Oral ulcers
  • Hair thinning
  • Hepatitis/cirrhosis
  • Pneumonitits
  • Bone marrow supression
19
Q

Side effects of hydroxychloroquine

A
  • GI disturbance
  • Retinal pigmentation and loss of vision - screening needed
  • No blood tests needed
20
Q

Side effects of sulfasalazine

A
  • GI upset
  • Rash
  • Hepatitis
  • Bone marrow supression
21
Q

Side effects Azathioprine

A
  • GI upset
  • Bone marrow supression
22
Q

Side effect of cyclophosphamide

A
  • Bone marrow supression
  • Infertility
  • Increase risk of cancer
23
Q

Ciclosporin side effectd

A
  • Renal impairement
  • HTN
24
Q

Leflunomide side effects

A
  • GI upset
  • HTN
  • Bone marrow supression
  • Hepatitis `
25
Q
A

Rheumatology YR3 (18 decks)

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