Single unit recoding and action Part 1 Flashcards
what is single unit recoding?
Recording from a single neuron using one or more microelectrodes
Safety concerns with S.U.R. in humans
Highly Invasive
- requires direct access to brain
- trauma to scalp and skull
- risk of infection
- insertion of electrodes may damage brain tissue
High threshold for use
- already entering brain for medical reasons
- potential to address severe disability
Ethical concerns with animals:
what is the points in favour of animal experiments?
Experimenting on animals is acceptible if suffering is minimized and human benifis are gained which could not be obtained by using other methods
Reasons against animal experiments
it causes suffering
the benefits to humans is not proven
any benefit to human beings that animals testing does provide could be produced in other ways
Types of recordings
Intracellular
- voltage clamp/current clamp
- patch clamp
Extracellular
- single unit recording
- Multi electrode recording
- field potentials
challenges in Spatial and temporal resolution
How to find the right neuron
How does this neuron relate to the other 100 billion
What is the cognitive map theory?
Memory for spacial relationships in environment
- place cells
fire when animal is in a particular location
-2014 Nobel prize in psychology
What is one example of a benefit of SUR in humans?
Brain-machine interface
What is an intracortical silicone microelectrode array used for?
to record from multiple units simultaneously
what is an implanted tetrode?
4 wires going down with a signal coming from each
the distance from each neuron to each tetrode is a little different
each of these will receive signals from different electrodes and there will be overlap
What is clustering
Finding AP that all look the same but are different from other ones
