Signal transduction of Inflammation

Question 1

3 receptor types are mentioned in this class which are?

Answer 1

IFN TNF TL

Question 2

during infection exogenous microbial products follows_____patterns

Answer 2

pathogen associated molecular patterns(PAMPs)

Question 3

during infection____molecules released by damaged tissues and____cells

Answer 3

endogenous
necrotic

Question 4

sterile inflammation follows___patterns

Answer 4

Damage associated molecular patterns

Question 5

Inflammation stimulus transduction
-LPS gram____cell wall
-________acids gram___cell wall
-____terminal sugar in microbial glycolipid/glycoprotein
-Bacterial/viral____,______
-N-_________
-_____and____strand viral____
-_____:fungal cell walls

Answer 5

gram negative
peptidoglycan/lipotechoic acids gram positive
mannose
bacterial/viral DNA, flagellin
formylmethionine
double and single strand RNA
glucans

Question 6

one of heat shock proteins released after tissue injury under DAMPs section what was its name?

Answer 6

HMGB1

Question 7

pattern-recognition receptors(PRR)
-membrane bound
-______receptors(TLRs)
-______receptors(MR)
-cytoplasmic
-NODs
-RLRs

Answer 7

toll
mannose

Question 8

TLR-2 is______charged and_____acid is one of its examples

Answer 8

positive
peptidoglycan/lipoteichoic acid

Question 9

TLR-4 is_____charged and_____&_____ is one examples of it

Answer 9

negative
HSP & HMGB1

Question 10

TLR-5 is bacterial_____

Answer 10

flagellin

Question 11

TLR-2, 4 and 5 are on____surface type PRRs

Answer 11

cell surface

Question 12

PRRs in endosomes are ?

Answer 12

TLR-3, 8, 9

Question 13

TLR-3 stimulated by viral____strand_____ during Inflammation stimuli

Answer 13

double strand DNA

Question 14

TLR-8 is stimulated by viral____strand_____ during Inflammation stimuli

Answer 14

single strand RNA

Question 15

TLR-9 is stimulated by____and____sequences during inflammation stimuli

Answer 15

viral and bacterial

Question 16

PRRs in cytoplasm are ?

Answer 16

NOD-2 and RIG-1

Question 17

NOD-2 is stimulated by_______dipeptide(bacterial peptoglycan) during Inflammation stimuli

Answer 17

muramyl

Question 18

RIG-2 is stimulated by viral____ during Inflammation stimuli

Answer 18

RNA

Question 19

_____part of TLRs is different from each other

Answer 19

Intracellular

Question 20

caspases activates____receptors by cleaving them

Answer 20

IL-1B

Question 21

____and____are responsible for fever and release of stress hormones

Answer 21

TNF-a and IL-1

Question 22

IL-6, 8 and interferon gamma are synthesized by____&____

Answer 22

TNF-a and IL-1

Question 23

______stimulate release of acute-phase reactans such as C-reactive protein(CRP)

Answer 23

Cytokines

Question 24

IL-6 stimulate release of______reactans

Answer 24

acute-phase

Question 25

IL__,_,__ stimulates chemotaxis, degranulation of neutrophils and their phagocytic activity

Answer 25

1,6,8

Question 26

TNF and IL 8 plays role stimulates______production _____ _____tosis

Answer 26

fever leukocytosis prostaglandins

Question 27

nitrogen balance drops to negative during____response

Answer 27

acute phase