Signal Transduction Flashcards
Signal transduction regulate several processes such as
Gene regulation
Protein modification
What are the 2 substances that are circulating in our bodies
Fat soluble
Water soluble
What are the coordinated response to stimulus
Gene transcription
Transporter channels
Protein translocation
Protein modification
What is the first requirement for signal transduction
Stimulus
Group 1 hormones are considered as what kind of soluble
Fat soluble (steroid hormones)
These hormones bind to intracellular receptors (considered as G1)
Androgens Calcitriol Estrogen Glucorticoid Mjneralocorticoid Progestin Retinoic acid Thyroid hormones
hormone derivative of iodine and cholesterol
Thyroid hormone (iodine)
Calcitriol (cholesterol)
What dissociates once the hormone attaches to the receptor
HSP (heat shock protein)
Heat shock protein act as what in the process
Molecular chaperone
What is a strong molecular chaperone that stops and modifies to prevent transcription and translation
Co-repressor
What are the intracellular messengers used in Group 2 hormones
Camp
CGMP
Calcium and phosphatidyl inositides
Kinase
Activation of what will produce secondary messenger
G-proteins
If the G protein uses cAMP as a the second messenger protein is will stimulate what
Protein Kinase A (PK-A)
What will be produce if G protein attaches to calcium-phosphatidyl inositides and DAG
Protein Kinase -C
What substance used cGMP only
Nitric oxide
Atrial Natriuretic factor (ANF)
Cholera toxin is what kind of ribosylation
Stimulatory
Pertussis toxin is what kind of ribosylation
Inhibitory
What inhibits denylate cyclase
Acetylcholine Angiotensin 2 Somatostatin Alpha adrenergics TSH
What do you add to the G protein to activate it
Phosphate
What are the G protein receptors
Adenylate cyclase
Phosphodiesterase
Protein kinase
What uses the tyrosine kinase cascade
EGF
Insulin
IGF-1
What uses JAK STAT
GH
Prl
EPO
Cytokines
3 substances that stimulate DNA
JAK STAT
CREB
cAMP
