side effects of antidepressants Flashcards
which SSRIs have lowest presence in breast milk
sertraline and paroxetine
what are some side effects of SSRI
GI upset
Anxiety and agitation
QT interval prolongation (especially associated with citalopram)
Sexual dysfunction - such as ED
Hyponatraemia
Gastric Ulcer
suicidal thoughts in young adults
which SSRI associated with long QT
citalopram
which SSRI associated with long QT
citalopram
TCA such as Doxepin SE
anticholinergic
Urinary retention
Drowsiness
Blurred vision
Constipation
Dry mouth
TCA such as Doxepin SE
anticholinergic
Urinary retention
Drowsiness
Blurred vision
Constipation
Dry mouth
CI
Contraindicated in those with previous heart disease
Can exacerbate schizophrenia
May exacerbate long QT syndrome
Use with caution in pregnancy and breastfeeding
May alter blood sugar in T1 and T2 diabetes mellitus
May precipitate urinary retention, so avoid in men with enlarged prostates
Uses the Cytochrome P450 metabolic pathway, so avoid in those on other CP450 medications or those with liver damage
what antidepressant is best in ischaemic heart disease
sertraline
omit in mania
when can you not use SNRI
Contraindicated in those with a history of heart disease and high blood pressure
need regular blood pressure monitoring
all antiD associated with suicide
serotonin syndrome features
restlessness
diaphoresis - sweat
clonus
hypethermia
rigidity
hyperrflexia
amphetmaiens both increase serotonergic transmission in the brain which can precipitate this too
TCA overdose features such as imipramine
confusion
seizure
tachycardia
hypotension
dilated pupils
prolonging of QRS and GTc interval
metabolic acidosis
treatment of TCA overdose is
supportive care and sodium bicarb
what recreational drugs can cause serotonin syndrome
ectasy and cocaine
exmaple of a NaSSA
noradrenergic and specific serotonergic antidepressant
mirtazapine
can you prescribe sertrlaien with anticoagulants in the elderly
not ideal try soemthing else like A NaSSA due to risk of bleeding
