Side Effects and Warnings

Question 1

Gentamicin

Answer 1

Ototoxicity
Nephrotoxicity
Neuromuscular blockage (Neurotoxicity)

Question 2

Tobramycin

Answer 2

Ototoxicity
Nephrotoxicity
Neuromuscular blockage (Neurotoxicity)

Question 3

Amikacin

Answer 3

Ototoxicity
Nephrotoxicity
Neurotoxicity

Question 4

Cipro

Answer 4

Ciprofloxacin

Teratogenic
QTc prolongation
Peripheral neuropathy
Tendon rupture
CNS effects (sizures)
Psych disturbancesr

Question 5

Levaquin

Answer 5

Levofloxacin

Teratogenic
QTc prolongation
Peripheral neuropathy
Tendon rupture
CNS effects (seizures)
Psych disturbances

Question 6

Moxifloxacin

Answer 6

FQ
Teratogenic
Tendon rupture
CNS effects
Psych disturbances
Peripheral neuropathy
QTc prolongation (MOST)

Question 7

Zithromax

Answer 7

Azithromycin
QTc prolongation
Hepatotoxicity

Question 8

Clarithromycin

Answer 8

QTc prolongation
CYP3A4 (Interactions) Warfarin
Hepatotoxicity

Question 9

Erthromycin

Answer 9

QTc prolongation (MOST)
CYP3A4 inhibitor (interaction with Warfarin)
Hepatotocixitiy

Question 10

Vibramycin

Answer 10

Doxycycline
Photosensitivity
Teratogenic

***no renal dose adjustments

Question 11

Minocin

Answer 11

Minocycline
Photosensitivity
Teratogenic
DILE —- lupus inducing

Question 12

Bactrim

Answer 12

SMX/TMP
CI: sulfa allergy
G6PD deficiency

SE: SJS, hyperkalemia, photosensitivity, hemolytic anemia, crystalurria, decrease in folate

*** only in D5W
*INCREASE INR with Warfarin use

Question 13

Vancomycin

Answer 13

Ototoxicity
Nephrotoxicity

Question 14

Telavancin

Answer 14

Nephrotoxicity
Teratogenic
QTc prolongation

Question 15

Daptomycin

Answer 15

Cubicin
Warning: myopathy (increase CPK)

**only in saline PACE w DIA

Question 16

Zyvox

Answer 16

Linezolid
CI: not within 2 weeks of MAO inhibitors

SE: thrombocytopenia, serotonin syndrome, hypoglycemia, neuropathy

Question 17

Synercid

Answer 17

Quinpristin/Dalfopristin
SE: myalgiasm hyperbilirubinemia

** in D5W only
ABS

Question 18

Tygacil

Answer 18

Tigecycline
Teratogenic
Hepatoxicity
Photosensity
Do not use for bloodstreatm infections!!!

Question 19

Colistimethate

Answer 19

Nephrotoxicity
Neurotoxicity
Prodrug into colistin

Question 20

Polymyxin B

Answer 20

Nephrotoxicity
Neurotoxicity

Question 21

Clindamycin

Answer 21

C diff!!!!!
N/V/D
SJS

Question 22

Metronidazole

Answer 22

CI: Teratogenic === do not use in 1st trimester or with alcohol (disulfiram rxn)
neuropathy / seizures
SE: metallic taste

Question 23

Macrobid

Answer 23

Nitrofurantoin
CrCl < 60 === DO NOT USE
G6PD deficiency = hemolytic anemia

SE: brown urine, GI upset

Question 24

What antibiotics have QTc prolongation?

Answer 24

Macrolides
Fluoroquinolones

Question 25

Which antibiotics have teratogenic effects?

Answer 25

Tetracyclines Fluoroquinolones Metronidazole (1st trimester) Bactrim

Question 26

What antibiotics should you watch out for G6PD deficiency for hemolytic anemia?

Answer 26

Macrobid Bactrim

Question 27

Isoniazid

Answer 27

Hepatitis/ Hepatotoxicity Peripheral neuropathy - need Pyridoxine (vit B6)

Question 28

Rifampin

Answer 28

Hepatotoxicity hemolytic anemia CYP inducer --- DI orange/red discoloration

Question 29

Pyrazinamide

Answer 29

Hepatotoxicity Hyperuricemia (GOUT)

Question 30

Ethambutol

Answer 30

Optic neuritis hepatotoxicity confusion/hallucinations