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ID > Side Effects and Warnings > Flashcards

Side Effects and Warnings Flashcards

1
Q

Gentamicin

A

Ototoxicity
Nephrotoxicity
Neuromuscular blockage (Neurotoxicity)

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2
Q

Tobramycin

A

Ototoxicity
Nephrotoxicity
Neuromuscular blockage (Neurotoxicity)

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3
Q

Amikacin

A

Ototoxicity
Nephrotoxicity
Neurotoxicity

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4
Q

Cipro

A

Ciprofloxacin

Teratogenic
QTc prolongation
Peripheral neuropathy
Tendon rupture
CNS effects (sizures)
Psych disturbancesr

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5
Q

Levaquin

A

Levofloxacin

Teratogenic
QTc prolongation
Peripheral neuropathy
Tendon rupture
CNS effects (seizures)
Psych disturbances

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6
Q

Moxifloxacin

A

FQ
Teratogenic
Tendon rupture
CNS effects
Psych disturbances
Peripheral neuropathy
QTc prolongation (MOST)

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7
Q

Zithromax

A

Azithromycin
QTc prolongation
Hepatotoxicity

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8
Q

Clarithromycin

A

QTc prolongation
CYP3A4 (Interactions) Warfarin
Hepatotoxicity

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9
Q

Erthromycin

A

QTc prolongation (MOST)
CYP3A4 inhibitor (interaction with Warfarin)
Hepatotocixitiy

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10
Q

Vibramycin

A

Doxycycline
Photosensitivity
Teratogenic

***no renal dose adjustments

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11
Q

Minocin

A

Minocycline
Photosensitivity
Teratogenic
DILE —- lupus inducing

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12
Q

Bactrim

A

SMX/TMP
CI: sulfa allergy
G6PD deficiency

SE: SJS, hyperkalemia, photosensitivity, hemolytic anemia, crystalurria, decrease in folate

*** only in D5W
*INCREASE INR with Warfarin use

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13
Q

Vancomycin

A

Ototoxicity
Nephrotoxicity

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14
Q

Telavancin

A

Nephrotoxicity
Teratogenic
QTc prolongation

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15
Q

Daptomycin

A

Cubicin
Warning: myopathy (increase CPK)

**only in saline PACE w DIA

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16
Q

Zyvox

A

Linezolid
CI: not within 2 weeks of MAO inhibitors

SE: thrombocytopenia, serotonin syndrome, hypoglycemia, neuropathy

17
Q

Synercid

A

Quinpristin/Dalfopristin
SE: myalgiasm hyperbilirubinemia

** in D5W only
ABS

18
Q

Tygacil

A

Tigecycline
Teratogenic
Hepatoxicity
Photosensity
Do not use for bloodstreatm infections!!!

19
Q

Colistimethate

A

Nephrotoxicity
Neurotoxicity
Prodrug into colistin

20
Q

Polymyxin B

A

Nephrotoxicity
Neurotoxicity

21
Q

Clindamycin

A

C diff!!!!!
N/V/D
SJS

22
Q

Metronidazole

A

CI: Teratogenic === do not use in 1st trimester or with alcohol (disulfiram rxn)
neuropathy / seizures
SE: metallic taste

23
Q

Macrobid

A

Nitrofurantoin
CrCl < 60 === DO NOT USE
G6PD deficiency = hemolytic anemia

SE: brown urine, GI upset

24
Q

What antibiotics have QTc prolongation?

A

Macrolides
Fluoroquinolones

25
Q

Which antibiotics have teratogenic effects?

A

Tetracyclines
Fluoroquinolones
Metronidazole (1st trimester)
Bactrim

26
Q

What antibiotics should you watch out for G6PD deficiency for hemolytic anemia?

A

Macrobid
Bactrim

27
Q

Isoniazid

A

Hepatitis/ Hepatotoxicity
Peripheral neuropathy - need Pyridoxine (vit B6)

28
Q

Rifampin

A

Hepatotoxicity
hemolytic anemia
CYP inducer — DI
orange/red discoloration

29
Q

Pyrazinamide

A

Hepatotoxicity
Hyperuricemia (GOUT)

30
Q

Ethambutol

A

Optic neuritis
hepatotoxicity
confusion/hallucinations

ID (4 decks)

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