MOA

Question 1

Bicillin LA

Answer 1

Pen G (IM)
inhibits bacterial cell wall synthesis by binding to PBPs to block peptodoglycan synthesis

Question 2

Fortaz

Answer 2

Ceftazidime
inhibits bacterial cell wall synthesis by binding to PBPs to block peptodoglycan synthesis

Question 3

Teflaro

Answer 3

Cefaroline
inhibits bacterial cell wall synthesis by binding to PBPs to block peptodoglycan synthesis

Question 4

Cefotan

Answer 4

Cefotetan
inhibits bacterial cell wall synthesis by binding to PBPs to block peptodoglycan synthesis

Question 5

Invanz

Answer 5

Ertapenem
inhibits bacterial cell wall synthesis by binding to PBPs to block peptodoglycan synthesis

no psuedomonas, acinobacter, or entercoccus activity :(

Question 6

Azactam

Answer 6

Azreonam
inhibits bacterial cell wall synthesis by binding to PBPs to block peptodoglycan synthesis

MONOBACTAM

Question 7

Gentamicin

Answer 7

Block 30S ribosubunit to block bacterial protein synthesis
TAT

Question 8

Amikacin

Answer 8

Block 30S ribosubunit to block bacterial protein synthesis
TA

Question 9

Tobramycin

Answer 9

Block 30S ribosubunit to block bacterial protein synthesis
TAT

Question 10

Vibramycin

Answer 10

Doxycycline
Block 30S ribosubunit to block bacterial protein synthesis
TAT

Question 11

Minocin

Answer 11

Minocycline
Block 30S ribosubunit to block bacterial protein synthesis
TAT

Question 12

Cipro

Answer 12

Ciprofloxacin
block DNA topoisonmerase IV and II (DNA gyrase) to prevent supercoiling of bacterial DNA

concentration dependent

Question 13

Levaquin

Answer 13

Levofloxacin
block DNA topoisonmerase IV and II (DNA gyrase) to prevent supercoiling of bacterial DNA

concentration dependent

Question 14

Levaquin

Answer 14

Levofloxacin
block DNA topoisonmerase IV and II (DNA gyrase) to prevent supercoiling of bacterial DNA

concentration dependent

Question 15

Avelox

Answer 15

Moxifloxacin
block DNA topoisonmerase IV and II (DNA gyrase) to prevent supercoiling of bacterial DNA

concentration dependent
**should NOT be used fo UTIs === does not concentrate :(

Question 16

Zithromax

Answer 16

Azithromycin
Block 50S ribosubunit to block bacterial protein synthesis

CLiMS

Question 17

Clarithromycin

Answer 17

Block 50S ribosubunit to block bacterial protein synthesis
CLiMS

Question 18

Erythromycin

Answer 18

Block 50S ribosubunit to block bacterial protein synthesis
CLiMS

Question 19

Zyvox

Answer 19

Linezolid
Block 50S ribosubunit to block bacterial protein synthesis
CLiMS

Question 20

Synercid

Answer 20

Quinupristin/Dalfopristin Block 50S ribosubunit to block bacterial protein synthesis
CLiMS

**covers Entercoccus faecium NOT faecalis

Question 21

Cleocin

Answer 21

Clindamycin
Block 50S ribosubunit to block bacterial protein synthesis
CLiMS

Question 22

Bactrim

Answer 22

Sulfamethoxazole/ Trimethoprim

SMX: interfers with bacterial folic acid synthesis by blocking DHFA –> PABA

TMP: DHFA –> tetrahydrofolate reductase of folic acid pathway

Question 23

Vanococin

Answer 23

Vancomycin
binds to D-alanyl-D-alanine to inhibit bacterial cell wall synthesis and block PG polymerization

Question 24

Talavancin

Answer 24

binds to D-alanyl-D-alanine to inhibit bacterial cell wall synthesis and block PG polymerization

Question 25

Oritavancin

Answer 25

binds to D-alanyl-D-alanine to inhibit bacterial cell wall synthesis and block PG polymerization

Question 26

Cubicin

Answer 26

Daptomycin Cyclin lipopeptide that inhibits all intracellular replication and binds to cell membrane to cause leakage

Question 27

Tygacil

Answer 27

Tigecycline Binds to 30S ribosubunit ----- related to tetracyclines

Question 28

Polymyxin B

Answer 28

acts as cationic detergent that damages bacterial cytoplasmic membrane causing LEAKAGE of gram (-) cells

Question 29

Colistimehtate

Answer 29

acts as cationic detergent that damages bacterial cytoplasmic membrane causing LEAKAGE of gram (-) cells

Question 30

Chloramphenicol

Answer 30

Binds to 50S subunit of ribosome

Question 31

Flagyl

Answer 31

Metronidazole causes a loss of helical DNA and strand breakage to inhibit protein synthesis

Question 32

Dificid

Answer 32

Fidaxomicin inhibits RNA polymerase for C difficile infections!!!!

Question 33

Rifaximin

Answer 33

blocks DNA dependent RNA polymerase to treat hepatic encephalopathy, traveler's diarrhea, or IBS with Diarrhea

Question 34

Macrobid

Answer 34

Nitrofurantoin bacterial cell wall inhibitor to treat uncomplicated UTI (cystitis)