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MOA Flashcards

1
Q

Bicillin LA

A

Pen G (IM)
inhibits bacterial cell wall synthesis by binding to PBPs to block peptodoglycan synthesis

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2
Q

Fortaz

A

Ceftazidime
inhibits bacterial cell wall synthesis by binding to PBPs to block peptodoglycan synthesis

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3
Q

Teflaro

A

Cefaroline
inhibits bacterial cell wall synthesis by binding to PBPs to block peptodoglycan synthesis

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4
Q

Cefotan

A

Cefotetan
inhibits bacterial cell wall synthesis by binding to PBPs to block peptodoglycan synthesis

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5
Q

Invanz

A

Ertapenem
inhibits bacterial cell wall synthesis by binding to PBPs to block peptodoglycan synthesis

no psuedomonas, acinobacter, or entercoccus activity :(

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6
Q

Azactam

A

Azreonam
inhibits bacterial cell wall synthesis by binding to PBPs to block peptodoglycan synthesis

MONOBACTAM

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7
Q

Gentamicin

A

Block 30S ribosubunit to block bacterial protein synthesis
TAT

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8
Q

Amikacin

A

Block 30S ribosubunit to block bacterial protein synthesis
TA

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9
Q

Tobramycin

A

Block 30S ribosubunit to block bacterial protein synthesis
TAT

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10
Q

Vibramycin

A

Doxycycline
Block 30S ribosubunit to block bacterial protein synthesis
TAT

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11
Q

Minocin

A

Minocycline
Block 30S ribosubunit to block bacterial protein synthesis
TAT

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12
Q

Cipro

A

Ciprofloxacin
block DNA topoisonmerase IV and II (DNA gyrase) to prevent supercoiling of bacterial DNA

concentration dependent

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13
Q

Levaquin

A

Levofloxacin
block DNA topoisonmerase IV and II (DNA gyrase) to prevent supercoiling of bacterial DNA

concentration dependent

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14
Q

Levaquin

A

Levofloxacin
block DNA topoisonmerase IV and II (DNA gyrase) to prevent supercoiling of bacterial DNA

concentration dependent

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15
Q

Avelox

A

Moxifloxacin
block DNA topoisonmerase IV and II (DNA gyrase) to prevent supercoiling of bacterial DNA

concentration dependent
**should NOT be used fo UTIs === does not concentrate :(

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16
Q

Zithromax

A

Azithromycin
Block 50S ribosubunit to block bacterial protein synthesis

CLiMS

17
Q

Clarithromycin

A

Block 50S ribosubunit to block bacterial protein synthesis
CLiMS

18
Q

Erythromycin

A

Block 50S ribosubunit to block bacterial protein synthesis
CLiMS

19
Q

Zyvox

A

Linezolid
Block 50S ribosubunit to block bacterial protein synthesis
CLiMS

20
Q

Synercid

A

Quinupristin/Dalfopristin Block 50S ribosubunit to block bacterial protein synthesis
CLiMS

**covers Entercoccus faecium NOT faecalis

21
Q

Cleocin

A

Clindamycin
Block 50S ribosubunit to block bacterial protein synthesis
CLiMS

22
Q

Bactrim

A

Sulfamethoxazole/ Trimethoprim

SMX: interfers with bacterial folic acid synthesis by blocking DHFA –> PABA

TMP: DHFA –> tetrahydrofolate reductase of folic acid pathway

23
Q

Vanococin

A

Vancomycin
binds to D-alanyl-D-alanine to inhibit bacterial cell wall synthesis and block PG polymerization

24
Q

Talavancin

A

binds to D-alanyl-D-alanine to inhibit bacterial cell wall synthesis and block PG polymerization

25
Q

Oritavancin

A

binds to D-alanyl-D-alanine to inhibit bacterial cell wall synthesis and block PG polymerization

26
Q

Cubicin

A

Daptomycin
Cyclin lipopeptide that inhibits all intracellular replication and binds to cell membrane to cause leakage

27
Q

Tygacil

A

Tigecycline
Binds to 30S ribosubunit
—– related to tetracyclines

28
Q

Polymyxin B

A

acts as cationic detergent that damages bacterial cytoplasmic membrane causing LEAKAGE of gram (-) cells

29
Q

Colistimehtate

A

acts as cationic detergent that damages bacterial cytoplasmic membrane causing LEAKAGE of gram (-) cells

30
Q

Chloramphenicol

A

Binds to 50S subunit of ribosome

31
Q

Flagyl

A

Metronidazole
causes a loss of helical DNA and strand breakage to inhibit protein synthesis

32
Q

Dificid

A

Fidaxomicin
inhibits RNA polymerase for C difficile infections!!!!

33
Q

Rifaximin

A

blocks DNA dependent RNA polymerase to treat hepatic encephalopathy, traveler’s diarrhea, or IBS with Diarrhea

34
Q

Macrobid

A

Nitrofurantoin
bacterial cell wall inhibitor to treat uncomplicated UTI (cystitis)

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