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Side Effects Flashcards

0
Q

SE of Imatinib

A

Fluid rentention, CHF

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1
Q

Catastrophic SE of asparaginase

A

Pancreatitis

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2
Q

Drug that causes erythromelalgia (throbbing/burning of hands and feet due to occlusion of small arteries)

A

Bromocriptine

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3
Q

Antibiotic commonly causing idiosyncratic aplastic anemia

A

Chloramphenicol

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4
Q

Occupational chemical exposure invariably causing aplastic anemia

A

Benzene

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5
Q

Anti-migraine drug that has been shown to cause retroperitoneal fibrosis

A

Methysergide (ergot derivative)

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6
Q

Teratogenic effect of ACE inhibitors

A

Fetal renal damage

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7
Q

Teratogenic effect of antiepileptic drugs

A

Neural tube defects

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8
Q

Teratogenic effect of phenytoin

A

Fetal hydrantoin syndrome

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9
Q

Teratogenic effect of oral hypoglycemic drugs

A

Neonatal hypoglycemia

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10
Q

Teratogenic effect of barbiturates

A

Neonatal dependence

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11
Q

Vaginal clear cell adenocarcinoma

A

Diethylstilbestrol

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12
Q

Teratogenic effect of ethanol

A

Fetal alcohol syndrome

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13
Q

This drug causes Ebstein’s anomaly

A

Lithium

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14
Q

Teratogenic effect of isotretinoin

A

Craniofacial malformation

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15
Q

Teratogenic effect of iodide

A

Congenital hypothyroidism

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16
Q

Teratogenic effect is Mobius sequence

A

Misoprostol

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17
Q

Teratogenic effect of penicillamine

A

Cutis laxa

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18
Q

Teratogenic effect of thalidomide

A

Phocomelia

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19
Q

Teratogenic effect of smoking

A

IUGR

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20
Q

Teratogenic effect of tetracycline

A

Tooth discoloration

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21
Q

Teratogenic effect of aminoglycosides

A

Ototoxicity

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22
Q

Teratogenic effect of methimazole

A

Aplasia cutis congenita

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23
Q

Teratogenic effect of sulfonamides

A

Kernicterus

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24
Teratogenic effect of fluroquinolones
Cartilage damage
25
Teratogenic effect of warfarin
1st trimester: chondrodysplasia 2nd trimester: CNS malformations 3rd trimester: bleeding diathesis
26
SE Pilocarpine
Miosis, Blurring of vision
27
SE Nicotine
Generalized ganglionic stimulation
28
SE Edrophonium, Neostigmine, Rivastigmine
DUMBBELSS ``` Diarrhea Urination Miosis Bronchospasm Bradycardia Excitation (skeletal muscle and CNS) Lacrimation Sweating Salivation ```
29
SE: Betanechol
Diarrhea
30
SE Atropine
Tachycardia, Mydriasis, Cyclopegia, Skin flushing
31
SE Pralidoxime
Muscle weakness
32
A cholinergic antagonist that causes urinary retention
Benztropine (Biperiden, Trihexyphenidyl)
33
A cholinergic antagonist that causes dry mouth, nasal dryness and is less toxic than beta agonists in patients with COPD and heart disease
Ipratropium, Tiotropium
34
SE Scopolamine
Drowsiness, blurring of vision, dry eyes, constipation
35
A cholinergic nicotinic antagonist causing postural hypotension
Hexamethonium
36
SE Dopamine
Cardiovascular disturbance, Arrhythmias
37
Rebound nasal congestion
Phenylephrine (Pseudoephedrine)
38
An alpha 2 agonist which has a side effect of rebound hypertension
Clonidine
39
An alpha 2 agonist which may cause hemolytic anemia
Methyldopa
40
SE Apraclonidine
blurring of vision, dry mouth, conjunctivitis
41
An alpha 1 blocker with a side effect of first dose orthostatic hypotension
Prazosin
42
SE Propanolol
Bronchospasm, Erectile dysfunction
43
SE Hydrochlorothiazide
Hypokalemic metabolic alkalosis ``` HYPERGLUC HyperGLYCEMIA HyperLIPIDEMIA HyperURICEMIA HyperCALCEMIA ```
44
SE Furosemide
Loop diuretic toxicities ``` Oh Dang! Ototoxicity hypokalemia Dehydration Allergy to Sulfa Nephritis Gout ```
45
SE Reserpine
Severe psychiatric depression, suicidal ideation
46
SE: Hydralazine
Reflex tachycardia
47
Causes Hypertrichosis
Minoxidil
48
SE Verapamil
Pretibial edema, Gingival hyperplasia, Sinus node depression
49
SE Nifedipine
Pretibial edema, Flushing
50
A parenteral vasodilator which can cause Cyanide toxicity
Nitroprusside
51
SE Captopril
Cough, hyperkalemia
52
SE Losartan
Hypotension, Teratogen, hyperkalemia
53
An ultra short acting nitrate that can cause methemoglobinemia
Amyl nitrite
54
SE Nitroglycerin
Reflex tachycardia, tolerance (transdermal)
55
SE Procainamide
Lupus-like syndrome
56
SE Disopyramide
Marked antimuscarinic effects
57
SE Lidocaine
CNS stimulation, Agranulocytosis (Tocainide) ``` Drugs that cause agranulocytosis Chloramphenicol Clozapine Co-trimoxazole Colchicine Aminopyrine Phenylbutazone PTU Indomethacin Tocainide ```
58
SE Flecainide
Proarrhythmic effects
59
SE Desmopressin
Hyponatremia, Hypertension
60
SE Sotalol
Sinus bradycardia, asthma, dose-related torsades de pointes
61
SE Amiodarone
Amiodarone Toxicity ``` Pulmonary fibrosis Paresthesias Tremors Thyroid dysfunction Corneal deposits Skin deposits ```
62
SE Adenosine
Flushing
63
SE Acetazolamide
Hyperchloremic metabolic acidosis, renal calcium stones
64
SE Spironolactone
``` Gynecomastia Some Drugs Create Awesome Knockers Spironolactone Digoxin Cimetidine Alcohol Ketoconazole ```
65
SE Conivaptan
Nephrogenic DI
66
SE Ezetimibe
Hepatotoxicity (increased with statin use)
67
What are the drugs that cause flushing?
``` Drugs that cause flushing V-A-N-C Vancomycin Adenosine Niacin Calcium channel blockers ```
68
SE Methylergonovine
Uterine spasm, Abortion
69
SE Misoprostol
Miscarriage, Teratogenic effect (Moebius effect)
70
SE Alprostadil
Priapism
71
SE Latanoprost
Permanent eye color change
72
SE G-CSF
Bone pain (arthralgia)
73
A class 1A anti-arrhythmic which causes Cinchonism (headache, vertigo, tinnitus)
Quinidine
74
Osmotic diuretic causing transient volume expansion
Mannitol
75
Causes transient volume expansion
Mannitol
76
A bile acid-binding resin causing bloating, Constipation, Gritty taste
Cholestyramine
77
SE Fluticasone
Oropharyngeal candidiasis
78
Drug that causes pancreatitis
Indomethacin can also cause serious hematologic reactions (aplastic anemia, thrombocytopenia)
79
SE Montelukast
Churg-Strauss Syndrome (rare)
80
SE Ferrous sulfate
Acute overdose: Necrotizing gastroenteritis | Chronic overload: Hemochromatosis
81
SE Epoetin Alfa
Pure red cell aplasia
82
SE Simvastatin
Hepatotoxicity, Nephropathy, Rhabdomyolysis
83
Anti-arrhythmic that causes flushing
Adenosine ``` Drugs that cause flushing V-A-N-C Vancomycin Adenosine Niacin Calcium channel blockers ```
84
Medications that may cause drug-induced lupus
``` It's HIPP to have lupus Hydralazine Isoniazid Procainamide Penicillamine ```
85
SE Gemfibrozil
Nausea, Rashes, Leukopenia, Hemoconcentration
86
Histamine antagonist that causes drowsiness
Diphenhydramine
87
SE Thiopental
Extension of CNS depressant actions, tolerance, dependence liability, acute intermittent porphyria
88
SE Sumatriptan
Chest pain, Coronary vasospasm
88
SE Heparin
Heparin induced thrombocytopenia
89
SE Clopidogrel
Thrombotic Thrombocytopenic Purpura
89
SE Warfarin
Warfarin induced skin necrosis (for protein C and S deficiency), Teratogen (bone defects, hemorrhage)
90
SE Dipyramidole
Headache
91
SE Aminocaproic acid
Thrombosis, hypotension, myopathy
93
SE Celecoxib
GI Bleeding, MI and Stroke (Rofecoxib, Valdecoxib)
94
SE Paracetamol
Hepatotoxicity
95
SE Methotrexate
Mucosal ulcers
96
SE Mycophenolate Mofetil
Neutropenia
97
SE Sulfasalazine
Hemolytic anemia, Methemoglobinemia
98
SE Probenecid
Nephrotic Syndrome, Aplastic Anemia
100
Anti-asthma drug that causes seizures
Theophylline
101
Drug that can cause Cerebral hemorrhage, Reperfusion, and Arrhythmias
Alteplase
102
SE Allopurinol
Peripheral neuritis, Aplastic anemia, Cataracts (Idiosyncratic)
103
SE Midazolam
causes anterograde amnesia and Rebound insomnia/anxiety
104
SE Flumazenil
Benzodiazepine withdrawal syndrome
105
SE Ethanol
Wernicke-Korsakoff Syndrome (Weird ACO-Ataxia,Confusion, Ophthalmoplegia) Liver disease, increased risk for Pancreatitis, arrhythmias, Fetal alcohol syndrome
106
SE Phenytoin
Hirsutism, Gingival hyperplasia, Teratogen (Fetal Hydrantoin Syndrome)
107
Anti-seizure drug with most number of mechanisms of action
Topiramate
108
SE Desflurane
A pulmonary irritant causing bronchospasm
109
SE Sevoflurane
Peripheral vasodilation, renal insufficiency
110
SE Isoflurane
Cathecholamine-induced arrhythmias
111
SE Enflurane
Spike and wave activity, Muscle twitching, breath holding, myocardial depression
112
SE Halothane
``` Post-operative hepatitis, malignant hyperthermia Fever Clonus Hypertension Acidosis Rhabdomyolysis Trismus ```
113
SE Ketamine
Increased ICP, emergence delirium
114
SE Aspirin
GI Toxicity, Hypersensitivity, HAGMA, Reye Syndrome in children SAMTER TRIAD Asthma Aspirin Sensitivity Nasal polyps
114
SE Vitamin K
Severe infusion reaction when administered too fast (dyspnea, chest and back pain)
114
SE Ketorolac
GI and Nephrotoxicity
115
SE Ibuprofen
GI bleeding
116
Drug that causes pancreatitis
Indomethacin can also cause serious hematologic reactions (aplastic anemia, thrombocytopenia)
117
SE Gabapentin
Dizziness, Sedation, Ataxia, Nystagmus, Tremor
118
SE Tubocurarine and Pancuronium
Recurarization Drugs used in lethal injection: thiopental Pancuronium Potassium chloride
119
Causes Euphoria and Megaloblastic anemia on prolonged exposure
Nitrous oxide
120
What anesthetic drugs are implicated in malignant hyperthermia?
Halothane, Succinylcholine
121
A non-depolarizing neuromuscular blocker causing bronchospasm. Also undergoes Hoffman elimination.
Atracurium
122
This results to a rare interaction of Succinylcholine and Halothane
Malignant Hyperthermia
123
An anti-parkinsonism drug that causes emesis and dyskinesia and is also contraindicated in patients with history of Psychosis.
Levodopa-Carbidopa
124
A dopamine agonist which may cause compulsive gambling, hypersexuality, overeating, and uncontrollable tendency to fall asleep.
Pramipexole (Ropinirole)
125
SE: Selegiline
Serotonin Syndrome when used with SSRI. ``` Serotonin Syndrome FAT CHD Fever Agitation Tremor Clonus Hyperreflexia Diaphoresis ```
126
A COMT inhibitor that causes orange urine.
Entacapone
127
An antiviral/antiparkinsonism drug that may cause Livedo Reticularis.
Amantadine ``` Drugs causing livedo reticularis A man reads FHM and GQ Amantadine Hydroxyurea Minocycline Gemcitabine Quinidine ```
128
SE: Chlorpromazine
Corneal and lens deposits
129
A typical antipsychotic that can cause retinal deposits. Also, it has the strongest autonomic effects. Only antipsychotic with fatal overdose.
Thioridazine
130
SE: Olanzapine
Weight gain
131
A typical antipsychotic that can cause extrapyramidal dysfunctions and neuroleptic malignant syndrome.
Haloperidol ``` Neuroleptic Malignant Syndrome (FEVER) Fever Encephalopathy Vitals unstable Elevated CPK Rigidity ```
132
SE: Clozapine
Agranulocytosis Drugs that cause agranulocytosis Clozapine Methimazole Chloramphenicol Reduces risk of suicide
133
An atypical antipsychotic causing marked hyperprolactinemia.
Risperidone
134
SE: Ziprasidone
QT prolongation
135
A mood stabilizer which causes nephrogenic DI and Ebstein's Anomaly.
Lithium
136
SE: Fluoxetine
Erectile dysfunction ``` A SORE PEniS can't Fuck Hard SSRIs Opiates Risperidone Ethanol Propanolol Estrogens Spironolactone Finasteride Hydrochlorothiazide ```
137
An antidepressant that can cause priapism
Trazadone ``` Drugs that can cause priapism Tigas PeniS Q, AyaW Bumaba Trazodone Papaverine Sildenafil Quetiapine Alprostadil Warfarin Bupropion ```
138
An antidepressant causing Amenorrhea-galactorrhea syndrome.
Amoxapine
139
SE: Morphine
Respiratory depression
140
SE: Methadone
Drug induced hyperthyroidism
141
SE: Tramadol
Seizure
142
Drug of abuse that causes necrotizing arteritis
Amphetamines
143
Overdose of this drug may cause crack lung or hemorrhagic alveolitis.
Cocaine
144
SE: Radioactive iodine
Permanent hypothyroidsm
145
A GnRH analog which causes temporary exacerbation of precocious puberty and prostate cancer.
Leuprolide
146
A thioamide which causes cholestatic jaundice and agranulocytosis. As a teratogen, exposure leads to Aplasia cutis congenita
Methimazole
147
SE: Ethinyl Estradiol
Thromboembolism, increases risk of endometrial and breast CA
148
SE: Diethylstilbestrol (DES)
Clear Cell Vaginal Adenocarcinoma
149
SE: Clomiphene
Multiple pregnancies (10%)
150
An insulin secretagouge which has a Disulfiram reaction
Chlorpropamide
151
SE: Glibenclamide
Cholestatic jaundice
152
SE: Metformin
Weight loss, vitamin B12 malabsorption
153
SE: Rosiglitazone
Cardiovascular events
154
SE: Troglitazone
Hepatotoxicity
155
A thiazolidinedione causing weight gain, dyslidemia, and congestive heart failure
Pioglitazone
156
SE: Acarbose
GI disturbances (flatulence, diarrhea, abdominal pain)
157
An incretin modulator that may cause acute pancreatitis
Exenatide
158
Anti-obesity drug that leads to steatorrhea, malabsorption of fat-soluble vitamins, and rebound weight gain upon discontinuation
Orlistat
159
SE: Rimonabant
Suicidality, depression, nausea
160
SE: Teriparatide
Hypercalcemia, hypercalciuria
161
SE: Calcitriol
Secondary hyperparathyroidism in CKD, Hypocalcemia in hypoparathyroidism
162
Drug that causes reactivation of latent tuberculosis
Infliximab
162
SE Azathioprine
Bone Marrow supression, increased incidence of lymphoma
162
May cause ocular toxicity
Chloroquine
164
Drug that commonly causes hemorrhagic cystitis
Cyclophosphamide
165
A vitamin D which may cause psoriasis
Calcipotriene
167
Antiseizure drugs that cause SJS
Carbamazipine, Lamotrigine
168
Local anesthetic with severe cardiovascular toxicity
Bupovacaine, Ropivacaine Treat with intralipid
169
SE Valproic Acid
Alopecia, Hepatotoxicity (infants), Teratogen (Spina bifida)
170
Drugs that can cause gingival hyperplasia
Nifedipine Cyclosporine Phenytoin Verapamil
171
Halothane
Post-operative Hepatitis, Malignant Hyperthermia (with Succinyl choline) ``` Malignant Hyperthermia (FCHART) Fever Clonus Hypertension Acidosis Rhabdomyolysis Trismus ```
171
This drug can cause Hallucinations and Psychosis
Levetiracetam
171
SE Etomidate
Myoclonus, Adrenocortical suppression
171
SE Fentanyl
Causes Respiratory depression, Chest wall rigidity, constipation antidote: NALAXONE
171
SE Propofol
Bradycardia, Hypotension
171
Local anesthetic with an adverse effect of antibody formation
Procaine
171
SE: Alendronate
Esophagitis
171
Most hepatotoxic general inhalational anesthetic
Halothane
171
Dangerous hypotension with PDE inhibitors like Sildenafil
Nitroglycerin
177
Drugs that can cause disulfiram reaction
``` Chlorpropamide Cefo Perazone - 3rd Mandole - 2nd Tetan - 2nd Procarbazine Metronidazole ```
178
Drugs that could cause pulmonary fibrosis
``` BBBAN Me Bleomycin Bromocriptine Busulfan Amiodarone Nitrofurantoin Metronidazole ```
179
What are Bactericidal Antibiotics?
``` Very Finely Proficient At Murder Vancomycin Fluoroquinolones Penicillins Aminoglycosides Metronidazole ```
180
These are Bacteriostatic Antibiotics
``` We're ECSTaTiC about bacteriostatics Erythromycin Clindamycin Sulfamethoxazole Trimethoprim Tetracycline Chloramphenicol ``` Sulfa+Trimethoprim=Bactericidal
181
Has complete cross-allergenicity with Cephalosporins
Penicillin
182
A penicillin which causes interstitial nephritis
Methicillin
183
SE of Nafcillin
Neutropenia
184
SE of Clavulanic acid
Cholestatic jaundice
185
A glycopeptide that causes Red Man Syndrome, nephrotoxicity, and Ototoxicity
Vancomycin
186
SE: Chloramphenicol
Aplastic Anemia, Gray Baby Syndrome
187
A 30s inhibitor causing tooth enamel dysplasia/discoloration
Tetracycline
188
SE: Clindamycin
Pseudomembranous colitis
189
A 50s inhibitor that can cause Arthralgia-myalgia syndrome
Quinuprustin-Dalfopristin
190
SE: Linezolid
Serotonin syndrome, optic neuritis
191
SE: Streptomycin
Ototoxicity
192
Most ototoxic aminoglycosides
Kanamycin, Amikacin
193
Most vestibulotoxic aminoglycosides
Tobramycin, Gentamycin
194
This sulfonamide may cause Kernicterus
SilverSulfadiazine
195
A 2nd generation fluoroquinolone resulting to tendinitis and tendon rupture
Ciprofloxacin
196
This fluoroquinolone may cause Diabetes
Gatifloxacin
197
A nitroimidazole which has a metallic taste
Metronidazole
198
SE: Rifampicin
Red-Orange urine
199
SE: Ethambutol
Visual disturbances (decreased visual acuity, red-green color blindness, retrobulbar neuritis, retinal damage)
200
Anti-TB drug which causes Asymptomatic Hyperuricemia
Pyrazinamide
201
SE: Dapsone
Methemoglobinemia
202
SE: Amphotericin B
Nephrotoxicity (RTA with magnesium and potassium wasting)
203
DOC for CMV retinitis which causes hypocalcemia
Foscarnet
204
SE: Zidovudine
Lactic acidosis with hepatic steatosis and bone marrow suppression
205
A protease inhibitor which may cause hyperlipidemia, fat redistribution, and Acanthosis Nigricans
Idinavir
206
SE: Amantadine
Livedo reticularis
207
This drug for influenza may cause bronchospasm in asthmatics
Zanamivir
208
SE: Quinine
Cinchonism (headache, tinnitus, vertigo) | Blackwater fever-intravascular hemolysis
209
An Anti-protozoal used in amoebiasis which causes thyroid enlargement
Iodoquinol
210
SE: Ivermectin
Mazzoti Reaction (Fever, headache, dizziness, rash, pruritus, tachycardia, hypotension, joint pains)
211
An ankylating agent causing hemorrhagic cystitis
Cyclophosphamide
212
SE: Dacarbazine
Phototoxicity
213
A vinca alkaloid causing paralytic ileus
Vincristine
214
SE: Doxorubicin
Dilated cardiomyopathy
215
SE: All-trans retinoic acid
Retinoic acid syndrome (dyspnea, fever, weight gain, peripheral edema)
216
SE: Prednisone
Adrenal suppression
217
SE: Magnesium-Aluminum Hydroxide
Metabolic Alkalosis (Milk-Alkali syndrome)
218
A mucosal protective agent that can cause black stools and darkening of the tongue
Bismuth salicylate
219
The DOC for diabetic gastroparesis which may cause Parkinsonism, EPS, and hyperprolactinemia
Metoclopramide
220
This causes malabsorption of the fat-soluble vitamins
Docusate
221
SE: Senna
Melanosis coli
222
SE: Penicillamine
Nephrotoxicity with proteinuria | Teratogen: cutis laxa

Pharmacology (4 decks)

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